Technetium-99M labeled peptides for imaging inflammation

Details Technetium-99M labeled peptides for imaging inflammation Technetium-99M labeled peptides for imaging inflammation

1995-06-05

1998-02-03

Leary, Louise

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530402, 530300, 424 111, 424 169, 534 14, 534 10, A61K 3800, A61K 5100, C07K 100, C07F 1300

Patent

active

057145792

ABSTRACT:
This invention relates to compositions that are radiolabeled scintigraphic imaging agents, comprising a polybasic compound covalently linked to a radiolabel binding moiety and the composition further comprising a polysulfated glycan. The invention also provides methods for producing and using such compositions. Specifically, the invention relates to compositions comprised of technetium-99m (Tc-99m) labeled scintigraphic imaging agents comprising a polybasic compound having at least 5 chemical functionalities that are basic at physiological pH and a radiolabel-binding moiety, the composition further comprising a polysulfated glycan, the composition being capable of specifically binding to inflammatory sites in vivo. Methods and kits for making such compositions, and methods for using such compositions to image sites of infection and inflammation in a mammalian body, are also provided.

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