Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1996-05-14
2000-06-13
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 111, 424 165, 530300, 530311, 530317, 534 14, A61K 5100, A61M 3614
Patent
active
060746270
ABSTRACT:
This invention relates to radiolabeled peptides and methods for producing such peptides. Specifically, the invention relates to peptides, methods and kits for making such peptides, and methods for using such peptides to image sites in a mammalian body labeled with technetium-99m (Tc-99m) via a radiolabel-binding moiety covalently attached to a specific binding peptide via an amino acid side-chain of the peptide.
REFERENCES:
patent: 4434151 (1984-02-01), Byrne et al.
patent: 4444690 (1984-04-01), Fritzberg
patent: 4472509 (1984-09-01), Gansow et al.
patent: 4571430 (1986-02-01), Byrne et al.
patent: 4575556 (1986-03-01), Byrne et al.
patent: 4615876 (1986-10-01), Troutner et al.
patent: 4673562 (1987-06-01), Eg et al.
patent: 4861869 (1989-08-01), Nicolotti et al.
patent: 4965392 (1990-10-01), Fritzberg et al.
patent: 4986979 (1991-01-01), Morgan, Jr. et al.
patent: 4988496 (1991-01-01), Svinivasan et al.
patent: 5061641 (1991-10-01), Shochat et al.
patent: 5225180 (1993-07-01), Dean et al.
patent: 5279811 (1994-01-01), Bergstein et al.
patent: 5382654 (1995-01-01), Lyle et al.
patent: 5405597 (1995-04-01), Dean et al.
patent: 5443815 (1995-08-01), Dean et al.
patent: 5552525 (1996-09-01), Dean
patent: 5686410 (1997-11-01), Albert et al.
patent: 5700444 (1997-12-01), Zamora et al.
patent: 5759515 (1998-06-01), Rhodes et al.
Tubis et al., 1968, "The Preparation of .sup.99m Technetium-Labeled Cystine, Methionine and a Synthetic Polypeptide and their Distribution in Mice", Int. J. Appl. Rad. Isot. 19:835-840.
Sundrehagen, 1983, "Formation of a [.sup.99m Tc]Polypeptide Hormone: Characterization and Chemical Quality Control by Ampholyte Displacement Radiochromatography", Int. J. Appl. Rad. Isot. 34: 1003.
Bryson et al., 1988, "Neutral Technetium(V) Complexes with Amide-Thiol-Thioether Chelating Ligands", Inorg. Chem. 27: 2154-2161.
Misra et al., 1989, "Synthesis of a Novel Diaminodithiol Ligand for Labeling Proteins and Small Molecules with Technetium-99m", Tet. Lett. 30: 1885-1888.
Baidoo & Lever, 1990, "Synthesis of a Diaminedithiol Bifunctional Chelating Agent for Incorporation of Technetium-99m into Biomolecules", Bioconjugate Chem. 1: 132-137.
Bryson et al., 1990, "Protecting Groups in the Preparation of Thiolate Complexes of Technetium", Inorg. Chem. 29: 2948-2951.
Taylor et al., 1990, "Brain Uptake and Retention of [Tc-99m]T691: A Potential New Tracer of Cerebral Blood Flow", J. Nucl. Med. 31: 885 (Abst).
Lister-James et al., "A Structure-Activity-Relationship (SAR) Study of Somatostatin Receptor-Binding Peptides Radiolabeled with TC-99m," Journal of Nuclear Medicine 35(5), 257P-258P (1994), No. 1056.
Zubay, "Protein Structure and Function," Biochemistry, pp. 3-7 (1983).
Buttram Scott
Civitello Edgar R.
Dean Richard T.
Lister-James John
McBride William
Dees Jos,e G.
Diatide, Inc.
Jones Dameron
McDaniels Patricia A.
Noonan Kevin E.
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