Technetium-99m-labeled organic germanium nanocolloids,...

Details Technetium-99m-labeled organic germanium nanocolloids,... Technetium-99m-labeled organic germanium nanocolloids,...

2006-06-26

2008-12-02

Hartley, Michael G. (Department: 1618)

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

C534S014000

Reexamination Certificate

active

07459141

ABSTRACT:
Disclosed relates to organic germanium nanocolloids, to which technetium-99m (99mTc), a radionuclide, is labeled, method of the same, and a spleen-imaging agent including the same. According to the invention,99mTc-labeled organic germanium nanocolloids having high labeling efficiency and stability can be provided. Moreover, since the99mTc-labeled organic germanium nanocolloids of the invention are accumulated in the spleen considerably higher than the conventional spleen-imaging agent, it is possible to use the99mTc-labeled organic germanium nanocolloids of the present invention as a therapeutic radiopharmaceutical for the spleen imaging.

REFERENCES:
Silvia, S.J.,, et al., Potential Technetium Small Molecule Radiopharmaceuticals, Chem. Rev., vol. 99, pp. 2205-2218, 1999.
Liu, Shuang, et al., 99mTc-Labeled Small Peptides as Diagnostic Radiopharmaceuticals, Chem. Rev., vol. 99, pp. 2235-2268, 1999.
Atkins, Harold L., et al., Splenic Sequestration of 99mTc Labeled . . . , Radiology, vol. 136, pp. 501-503, 1980.

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