Technetium-99m labeled chelator incorporated cyclic peptides tha

Details Technetium-99m labeled chelator incorporated cyclic peptides tha Technetium-99m labeled chelator incorporated cyclic peptides tha

1997-10-01

1999-03-30

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 11, 530317, 424 169, A61K 3800, A61K 3940, C07K 500, C07K 1600

Patent

active

058889701

ABSTRACT:
The present invention describes novel radiopharmaceuticals of formula (I): ##STR1## wherein J, K, L, and M, are amino acids or derivatives thereof and R', R.sup.1, R.sup.2 and n are as defined herein, that are radiolabeled cyclic compounds containing chelators which act as antagonists of the platelet glycoprotein IIb/IIIa complex, methods of using the same as imaging agents for the diagnosis of arterial and venous thrombi, and novel reagents for the preparation of the same and kits comprising the reagents.

REFERENCES:
patent: 5443816 (1995-08-01), Zamora et al.
patent: 5635477 (1997-06-01), Degrado et al.
Lister-James et al., Technetium and Rhenium in Chemistry and Nuclear Medicine SGEditoriali: Padova, 1995, 269-274, "Technetium-99m Chelate Containing Receptor-binding Peptides".
Lister-James et al., Journal of Nuclear Medicine 1995, 16P-17P, "Tc-99M P748. A Receptor-Binding Techtide.TM. for Imaging Activated Platelets".
Lister-James et al., Quarterly Journal of Nuclear Medicine 1996, 40, 221-233, "Small Peptides Radiolabeled with .sup.99m Tc".
Knight et al., Journal of Nuclear Medicine 1994, 35, 282-288, "Thrombus Imaging with Technetium-99m Synthetic Peptides Based upon the Binding Domain of a Monoclonal Antibody to Activated Platelets".

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