Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2011-05-03
2011-05-03
Noakes, Suzanne M (Department: 1656)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S320100, C435S325000, C435S252100, C435S252300, C435S254110, C435S419000, C435S254200
Reexamination Certificate
active
07935801
ABSTRACT:
An isolated nucleic acid sequence encoding a non-oligomerizingClavulariateal fluorescent protein (TFP) variant having a tyrosine-derived chromophore, and fragments and derivatives thereof. Also provided is a method for engineering the nucleic acid sequence, a vector comprising the nucleic acid sequence, a host cell comprising the vector, and use of the vector in a method for expressing the nucleic acid sequence. The present invention further provides an isolated nucleic acid, or mimetic or complement thereof, that hybridizes under stringent conditions to the nucleic acid sequence. Additionally, the present invention provides a non-oligomerizing TFP variant encoded by the nucleic acid sequence, as well as derivatives, fragments, and homologues thereof. Also provided is an antibody that specifically binds to the TFP variant. The present invention further provides a tandem dimer comprising two TFP dimers, operatively linked by a peptide linker.
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Al Hu-Wang
Campbell Robert Earl
Bennett Jones LLP
Lee Jae W
Noakes Suzanne M
The Governors of the University of Alberta
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