Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-06-30
2008-10-21
Stucker, Jeffrey (Department: 1649)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C530S402000, C435S069700
Reexamination Certificate
active
07439328
ABSTRACT:
A polypeptide may include an amino acid sequence having at least about 95% identity to the amino acid sequence of SEQ ID NO: 42, wherein a residue at position 94 of the polypeptide is an amino acid other than threonine or wherein a residue at position 82 of the polypeptide is an amino acid other than serine. A polypeptide may include at least the first 14 residues and at most the first 92 residues of an amino acid sequence starting with residue 1 of, and having at least about 95% identity to, the amino acid sequence of SEQ ID NO: 1, 3, 5, 7, 9, 11, 13, 15, 16, or 17. Such polypeptide may stimulate neurite outgrowth or neurogenesis. A nucleic acid may encode the polypeptide. A vector may include the nucleic acid. A host cell, such as an embryonic stem cell, may include the vector.
REFERENCES:
Wells, Biochemistry 29:8509-8517, 1990.
Ngo et al.,The Protein Folding Problem and Tertiary Structure Prediction, pp. 492-495, 1994.
Chuang et al. Dev Cell 9: 75-86, 2005.
Bork, Genome Research 10:398-400, 2000.
Skolnick et al., Trends in Biotech. 18(1): 34-39, 2000.
Doerks et al., Trends in Genetics 14:248-250, 1998.
Smith et al., Nature Biotechnology 15:1222-1223, 1997.
Brenner, Trends in Genetics 15:132-133, 1999.
Bork et al., Trends in Genetics 12:425-427, 1996.
Kai et al. “Molecular cloning of Fyn-associated molecules in the mouse central nervous system.”Journal Neuroscience Research, vol. 48, pp. 407-424, 1997.
Chuang, Jen-Zen, et al.; “A 29 kDa Intracellular Chloride Channel p64H1 Is Associated with Large Dense-Core Vesicles in Rat Hippocampal Neurons”;The Journal of Neuroscience, Apr. 15, 1999, 19(8): pp. 2919-2928.
Chuang, Jen-Zen; “Dynein light chain Tctex-1, a novel marker for adult hippocampal progenitors, is essential for neuronal development”;Mol. Biol. Cell, 2003; 14 (Suppl.): p. 1753.
Chuang, Jen-Zen, et al.; “Subunit Heterogeneity of Cytoplasmic Dynein: Differential Expression of 14 kDa Dynein Light Chains in Rat Hippocampus”;The Journal of Neuroscience, Aug. 1, 2001, 21 (15); pp. 5501-5512.
Tai, Andrew W., et al.; “Cytoplasmic Dynein Regulation by Subunit Heterogeneity and Its Role in Apical Transport,”The Journal of Cell Biology, vol. 153, No. 7, Jun. 25, 2001, pp. 1499-1509.
Tai, Andrew W., et al.; “Localization of Tctex-1, a Cytoplasmic Dynein Light Chain, to the Golgi Apparatus and Evidence for Dynein Complex Heterogeneity”;The Journal of Biological Chemistry; vol. 273, No. 31 Issue of Jul. 31, 1998, pp. 19639-19649.
Tai, Andrew W., et al.; “Rhodopsin's Carboxy-Terminal Cytoplasmic Tail Acts as a Membrane Receptor for Cytoplasmic Dynein by Binding to the Dynein Light Chain Tctex-1”;Cell, vol. 97; Jun. 25, 1999; pp. 877-887.
Yano, Hiroko, et al.; “Association of Trk Neurotrophin Receptors with Components of the Cytoplasmic Dynein Motor”,The Journal of Neuroscience, 2001, vol. 21 RC 125, pp. 1-7.
Chuang Jen-Zen
Sung Ching-Hwa
Cornell Research Foundation Inc.
Dutt Aditi
Foley & Hoag LLP
Kamholz Scott E.
Stucker Jeffrey
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