TCR-independent activation of T cells

Details TCR-independent activation of T cells TCR-independent activation of T cells

2006-05-08

2011-10-04

Ouspenski, Ilia (Department: 1644)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

Reexamination Certificate

active

08029792

ABSTRACT:
A method for TCR-independent T cell activation which comprises the co-ligation of CD28 and CD81.

REFERENCES:
patent: 6294167 (2001-09-01), Lindhofer et al.
patent: 2003/0077273 (2003-04-01), Linnik et al.
Sheridan C., 2006, Nature Biotechnology, 24: 475-476.
Cibotti, et al., “Surface Molecules that Drive T Cell Development In Vitro in the Absence of Thymic Epithelium and in the Absence of Lineage-Specific Signals,”Immunity6(3):245-255 (1997).
Elflein, et al., “Rapid Recovery from T Lymphopenia by CD28 Superagonist Therapy,”Blood102(5):1764-1770 (2003).
Lin, et al., “Efficient Expansion of Regulatory T Cells In Vitro and In Vivo with CD28 Superagonist,”Eur J Immunol33(3):626-638 (2003).
Schmidt, et al., “Treatment and Prevention of Experimental Autoimmune Neuritis with Superagonistic CD28-Specific Monoclonal Antibodies,”J Neuroimmunology140(1-2):143-152 (2003).
Wack, et al., “Binding of the Hepatitus C Virus Envelope Protein E2 to CD81 Provides a Co-Stimulatory Signal for Human T Cells,”Eur J Immunol31(1):166-175 (2001).
Witherden, et al., “CD81 and CD28 Costimulate T Cells Through Distinct Pathways,”J Immunol165(4):1902-1909 (2000).
Witherden, et al., “CD81 and CD28 Costimulate T Cells Through Distinct Pathways,”FASAB J13(4):A627 (1999).

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