TCL-5 gene rearrangement involved in T-cell leukemia and melanom

Details TCL-5 gene rearrangement involved in T-cell leukemia and melanom TCL-5 gene rearrangement involved in T-cell leukemia and melanom

1991-03-20

1993-09-07

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 536 231, 935 77, 935 78, C12Q 168, C12P 1934, C07H 1512

Patent

active

052427951

ABSTRACT:
A gene is described which is involved in the neoplastic process of a number of different cancers. The gene, termed TCL-5, is located at chromosome 1, band 32, adjacent to the chromosome junction formed during a t(1;14)(p32;q11) translocation. Probes and primers for detecting TCL-5 rearrangements are provided, as well as methods for detecting abnormalities in TCL-5 expression.

REFERENCES:
Lee et al., Science 237:175-178 (Jul. 10, 1987).
Finger et al., Science 234:982-985 (Nov. 21, 1986).
Gilbert et al., "Abnormalities of Chromosome 1p in Human Neuroblastoma Tumors and Cell Lines," Cancer Genet. Cytogenet., 1982, 7:33-42.
Hershfield, et al., "Conversion of a Stem Cell Leukemia from a T-lymphoid to a Myeloid Phenotype Induced by the Adenosine Deaminase Inhibitor 2'-deoxycoformycin," Proc. Natl. Acad. Sci. USA, 1984, 81:253-257.
Croce, et al., "Gene for alpha-chain of Human T-Cell Receptor: Location on Chromosome 14 Region Involved in T-Cell Neoplasms," Sci., 1985, 227:1044-1047.
Kurtzberg, et al., "Establishment of the DU.528 Human Lymphohemmopoietic Stem Cell Line," J. Exp. Med., 1985, 162:1561-1578.
Balaban, et al., "Karyotypic Evolution in Human Malignant Melanoma," Cancer Genet. Cytogenet., 1986, 19:113-122.
Raimondi, et al., "7q32-q36 Translocations in Childhood T-Cell Leukemia: Cytogenetic Evidence for Involvement of the T-Cell Receptor beta-Chain Gene," Blood, 1987, 69:131-134.
Rabbits, et al., "Chromosomal Abnormalities in Lymphold Tumours: Mechanism and Role in Tumour Pathogenesis," Trends Genet., 1988, 4:300-304.
Haluska, et al., "Localization of the Human JUN Protooncogene to Chromosome Region 1p31-32," Proc. Natl. Acad. Sci. USA, 1988, 85:2215-2218.
Isobe, et al., "Cloning of the Gene Encoding the beta subunit of the Human T-Cell Receptor Reveals its Physical Organization within the alpha-subunit Locus and its Involvement in Chromosome Translocations in T-Cell Malignancy," Proc. Natl. Acad. Sci. USA, 1988, 85:3933-3937.
Begley, et al., "Chromosomal Translocation in a Human Leukemic Stem-Cell Line Disrupts the T-Cell Antigen Receptor beta-Chain Diversity Region and Results in a Previously Unreported Fusion Transcript," Proc. Natl. Acad. Sci. USA, 1989, 86:2031-2035.
Bale, et al., "Mapping the Gene of Hereditary Cutaneous Malignant Melanoma-Dysplastic Nevus to Chromosome 1p," N. Eng. J. Med., 1989, 320:1367-1372.

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