TC or RE radionuclide labelled chelate, hexapeptide complexes us

Details TC or RE radionuclide labelled chelate, hexapeptide complexes us TC or RE radionuclide labelled chelate, hexapeptide complexes us

1994-10-13

1996-09-17

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Somatostatin ; related peptides

530321, 530345, 534 10, 534 14, 930160, A61K 3812, A61K 5108, C07F 1300, C07K 764

Patent

active

055569390

ABSTRACT:
Technetium or rhenium radionuclide labelled chelate-hexapeptide complexes are useful for the selective detection or treatment of tumors with somatostatin receptors. In particular, compounds of formula: ##STR1## (wherein R, R.sup.1, R.sup.3 and A are as defined herein) incorporating an N3S2 chelate may be labelled with a radionuclide. The resulting complexes are useful as radioimaging agents or as radiopharmaceuticals for the treatment of certain tumors.

REFERENCES:
patent: 3780015 (1975-12-01), Hirschmann et al.
patent: 5225180 (1993-07-01), Dean et al.
patent: 5382654 (1995-01-01), Lyle et al.
Nucl. Med. Biol., vol. 15, No. 2, issued 1988, Chiotellis et al, "Comparctive Evaluation of .sup.99m Tc-labeled Aminothiols . . . ", pp. 215-223.
Reubi, J. C., et al., Cancer Research, 47, pp. 5758-5764, Nov. 1, 1987.
Spanevello, R. A., et al., Tetra. Letters, vol. 32, pp. 4675-4678, 1991.

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