Tbc1 gene and uses thereof

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

530350, C12N 1512, C07K 14475

Patent

active

057009279

ABSTRACT:
Disclosed is a substantially pure DNA encoding a Tbc1 polypeptide; a substantially pure Tbc1 polypeptide; and methods of using such DNA to express Tbc1 in leukemic stem cells and treat certain leukemias. Also disclosed are methods for diagnosing other leukemias and spermatogenesis disorders by assaying for Tbc1 expression.

REFERENCES:
patent: 5302706 (1994-04-01), Smith, Jr.
Ackerman, S.J., et al., "Expression of Gata-Binding Proteins in Human Eosinophils and Basophils: Potential Role in Gene Transcription"; The Faseb Journal, A1435:2893 (1992).
Bennett, J.M., et al., "Proposals for the classification of the myelodysplastic syndrome"; British Journal of Hermatology, 51:189-199, (1982).
Castaigne, S., et al., "All-Trans Retinoic Acid as a Differentiation Therapy for Acute Promyelocytic Leukeimia. I. Clinical Results"; Blood 76:1704-1709 (1990).
Castaigne, S., et al., "Does Treatment with ARA-C in Low Dosage Cause Differentiation of Leukemic Cells?"; Blood 62:85-86 (1983).
Desforges, Jane F., "Cytarabine: Low-Dose, High-Dose, No Dose?"; The New England Journal of Medicine, 309:1637-1638 (1983).
Fialkow, P.J., et al., "Evidence that Essential Thrombocythemia is a Clonal Disorder With Origin in a Multipotent Stem Cell"; Blood 58:916-919 (1981).
Fialkow, P.J., et al., "Expression in Cells Restricted to Granulocytic and Monocytic Differentiation"; The New England Jouranl of Medicine, 301:1-5 (1979).
Grier, H.E., et al., "Chronic Myeloproliferative Disorders"; Acute and Chronic Myeloproliferative Disorders and Myelodysplasia, 36:1288-1318.
Meng-er, H. et al., "Use of All-Trans Retinoic Acid in Treatment of Acute Promyelocytic Leukemia"; Blood, 72:567-572 (1988).
Mouthon, M. et al., "Expression of tal-1 and GATA-Binding Proteins During Human Hematopoiesis"; Blood 81:647-655 (1993).
Pevny, L., et al., "Erthroid differentiation in chimaeric mice blocked by a targted mutation in the gene for transcription factor GATA-1"; Nature 349:257-349 (1991).
Richardson, P. et al., "Cloning of Potential Targest of GATA-1 Activation During Mast Cell Development"; Journal of Cellular Biochemistry, B679:170 (1993).
Schrier, Stanley L., "VIII The Leukemias and the Myeloproliferative Disorders"; HEMA 5:1-28 (1989).
Tsai, S.F., "Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter"; Genes & Development, 5:919-931 (1991).
Visvader, J. et al., "Megakaryocytic Differentiation Induced in 416B Myeloid Cells by GATA-2 and GATA-3 Transgenes or 5-Azacytidine is Tightly Coupled to GATA-1 Expression"; Blood, 82:1493-1501 (1993).
Visvader, J.E. et al., "GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid line"; The EMBO Journal, 11:4557-4564 (1992).
Wisch, J. S. et al., "Response of Preleukemic Syndromes to Continuous Infusion of Low-Dose Cytarabine"; The New England Journal of Medicine, 309:1599-1602 (1983).
Zon, L. et al., "GATA-binding Transcription Factors in Mast Cells Regulate the Promoter of the Mast Cell Carboxypeptidase A Gene"; The Journal of Biological Chemistry, 266:22948-22953 (1991).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Tbc1 gene and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tbc1 gene and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tbc1 gene and uses thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1803635

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.