Taxol process and compounds

Details Taxol process and compounds Taxol process and compounds

1996-01-19

1998-06-02

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549511, C07D30514

Patent

active

057602514

ABSTRACT:
A process for the preparation of taxol and derivatives of taxol ##STR1## is disclosed. The process involves reacting a .beta.-alkoxycarbonylamino-phenylpropionic acid with a 13-hydroxy taxane to produce an ester of the taxane at C-13; and then deprotecting the .beta.-alkoxycarbonylamino-phenylpropionic ester to produce a .beta.-amido-.alpha.-hydroxybenzenepropanoic ester of the taxane. Intermediates useful in the process are also disclosed.

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