Taxol formulation

Details Taxol formulation Taxol formulation

1993-11-12

1995-05-16

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

A61K 9127, A61K 9133

Patent

active

054158699

ABSTRACT:
The present invention relates to a pharmaceutical composition for use in treatment of cancer patients. The composition includes at least one taxane present in a pharmaceutical effective amount and a mixture of one or more negatively charged phospholipids and one or more zwitterion (i.e. uncharged) phospholipids. This mixture entraps the at least one taxane in what is believed to be a liposome. The mixture contains a ratio of negatively charged phospholipids to zwitterion phospholipids of 1:9 to 7:3. The taxol is present in an amount of 1.5-8.0 mole percent taxane. The composition is in the form of particles having a size of 0.025 to 10 microns with substantially no taxane crystals.

REFERENCES:
patent: 4534899 (1985-08-01), Sears
patent: 4873088 (1989-10-01), Mayhew et al.
patent: 4891208 (1990-01-01), Janoff et al.
patent: 4981690 (1991-01-01), Lopez-Berestein et al.
patent: 4994440 (1991-02-01), Creaven
patent: 5010073 (1991-04-01), Kappas et al.
patent: 5013556 (1991-05-01), Woodle et al.
patent: 5049322 (1991-09-01), Devissaguet et al.
patent: 5117022 (1992-05-01), Khokhar et al.
patent: 5118528 (1992-06-01), Fessi et al.
patent: 5132290 (1992-07-01), Priebe et al.
patent: 5133908 (1992-07-01), Stainmesse et al.
patent: 5174930 (1992-12-01), Stainmesse et al.
patent: 5190761 (1993-03-01), Liburdy
patent: 5213804 (1993-05-01), Martin et al.
patent: 5248796 (1993-09-01), Chen et al.
Straubinger, et al., "Novel Taxol Formulations: Taxol-Containing Liposomes," Journal of the National Cancer Institute Monographs, 15:69-78 (1993).
Straubinger, et al., "Pharmacology and Efficacy of Novel Taxol Formulations", Second National Cancer Institute Workshop On Taxol and Taxus, Sep. 23-24, 1992 (abstract).
R. Perez-Soler et al., "Phase I Clinical and Pharmacological Study of Liposome-entrapped cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane Platinum(II)," Cancer Research 50:4254-59 (1990).
J. Riondel, et al., "Effects of Free and Liposome--Encapsulated Taxol on Two Brain Tumors Xenografted into Nude Mice," In Vivo 6:23-28 (1992).
Bartoli, M-H., et al., "In Vitro and In Vivo Antitumoral Activity of Free, and Encapsulated Taxol," J. Microencapsulation 7(2):191-97 (1990).

Affiliated with

Also associated with

Rating

Taxol formulation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Taxol formulation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Taxol formulation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-636414