Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-07-14
1989-03-21
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549510, A01N 4302, C07D30500
Patent
active
048144703
ABSTRACT:
Taxol derivatives of formula ##STR1## in which R represents hydrogen or acetyl, one of R.sub.1 or R.sub.2 represents hydroxy and the other represents tert-butoxycarbonylamino and their isomers are useful antitumor agents.
REFERENCES:
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M. E. Jung et al, Jour. Chem. Soc., Chem. Comm. (1978), pp. 315-316.
R. S. Lott et al, Jour. Chem. Soc., Chem. Comm. (1979), pp. 495-496.
E. Herranz et al, Jour. Am. Chem. Soc., vol. 100:11 (1978), pp. 3596-3598.
Theodora W. Greene, Protective Groups in Organic Synthesis (1981), pp. 223, 225 and 232.
Colin Michel
Guenard Daniel
Gueritte-Voegelein Francoise
Potier Pierre
Hollrah Glennon H.
Rhone-Poulenc Sante
Russell Mark W.
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