Taxol derivatives

Details Taxol derivatives Taxol derivatives

1992-06-18

1993-09-28

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549511, C07D30514

Patent

active

052487962

ABSTRACT:
The present invention relates to 10-desacetoxy-11,12-dihydrotaxol-10,12(18)-diene derivatives which are useful as antitumor agents and as intermediates for the preparation of 10-desacetoxytaxol. Also disclosed is a novel process for the preparation of 10-desacetoxytaxol which comprises treating hydroxy protected 10-deacetyltaxol with 1,1,2-trifluoro-2-chlorotriethylamine followed by catalytic hydrogenation.

REFERENCES:
patent: 4243594 (1981-01-01), Beale et al.
Gamini Samaranayake et al, "Modified Taxols. 5. Reaction of Taxol with Electrophilic Reagents and Preparation of a Rearranged Taxol Derivative with Tubulin Assembly Activity," Journal of Organic Chemistry, 1991, vol. 56, pp. 5114-5119.
N. N. Yarovenko et al, "Fluorination by Means of .alpha.-Fluorinated Amines," Journal of Organic Chemistry USSR (English), 1959, vol. 29, pp. 2125-2128.
Lawrence H. Knox et al, "Steroids. CCXL. The Reaction of Steroidal Alcohols with 2-Chloro-1,1,2-trifluorotriethylamine," Journal of Organic Chemistry, Aug. 1964, vol. 29, pp. 2187-2195.
David G. I. Kingston et al, "The Chemistry of Taxol, A Clinically Useful Anticancer Agent," Journal of Natural Products, Jan.-Feb. 1990, vol. 53, No. 1, pp. 1-12.

Affiliated with

Also associated with

Rating

Taxol derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Taxol derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Taxol derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2192063