Taxoids, their preparation and pharmaceutical compositions conta

Details Taxoids, their preparation and pharmaceutical compositions conta Taxoids, their preparation and pharmaceutical compositions conta

1996-03-26

1998-12-08

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549511, C07D30514

Patent

active

058471707

ABSTRACT:
New taxoids of general formula (I): ##STR1## their preparation and pharmaceutical compositions containing them, and the new products of general formula (I) in which Z represents a radical of general formula (II): ##STR2## display noteworthy antitumour and antileukaemic properties.

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Greene et al, "Protective Groups in Organic Synthesis", pp. 10-14, 2.sup.nd edition, 1991.
M.L. Shelanski et al., "Microtubule Assembly in the Absence of Added Nucleotides", Proc. Natl. Acad. Sci. vol. 70, No. 3,pp. 765-768 (1973).
G. Chauviere et al., "Analyse structurable et etude biochimique de produits isoles de l'if: Taxus baccata L. (Taxaces)", C.R. Acad. Sc. Paris, t.293, pp. 501-503 (1981).
J. Kant et al., "A Chemoselective Approach to Functionalize the C-10 Position of 10-Deacetylbaccatin III. Synthesis and Biological Properties of Novel C-10 Taxol Analogues", Tetrahedron Letters, vol. 35, No. 31, pp. 5543-5546, 1994.

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