Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-10-02
1999-09-28
Trinh, Ba K.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
549511, 514449, C07D30514
Patent
active
059591250
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to new taxoids of general formula: ##STR2## in which: R represents substituted with a halogen atom chosen from fluorine, chlorine, bromine and iodine atoms or with an amino radical, an alkylamino radical in which the alkyl portion contains 1 to 4 carbon atoms, a dialkylamino radical in which each alkyl portion contains 1 to 4 carbon atoms or, with the nitrogen atom to which it is linked, forms a saturated 5- or 6-membered heterocyclic radical optionally containing a second hetero atom chosen from oxygen, sulphur and nitrogen atoms (and optionally substituted with an alkyl radical containing 1 to 4 carbon atoms or a phenyl radical or a phenylalkyl radical in which the alkyl portion contains 1 to 4 carbon atoms), a carboxyl radical, an alkyloxycarbonyl radical in which the alkyl portion contains 1 to 4 carbon atoms, a cyano or carbamoyl radical, an N-alkylcarbamoyl radical in which the alkyl portion contains 1 to 4 carbon atoms or an N,N-dialkylcarbamoyl radical in which each alkyl portion contains 1 to 4 carbon atoms or, with the nitrogen atom to which it is linked, forms a saturated 5- or 6-membered heterocyclic radical optionally containing a second hetero atom chosen from oxygen, sulphur and nitrogen atoms (and optionally substituted with an alkyl radical containing 1 to 4 carbon atoms or a phenyl radical or a phenylalkyl radical in which the alkyl portion contains 1 to 4 carbon atoms), branched chain, an alkynyl radical containing 2 to 8 carbon atoms in an unbranched or branched chain, a cycloalkyl radical containing 3 to 6 carbon atoms or a cycloalkenyl radical containing 3 to 6 carbon atoms, these radicals being optionally substituted with a halogen atom chosen from fluorine, chlorine, bromine and iodine atoms or with an amino radical, an alkylamino radical in which the alkyl portion contains 1 to 4 carbon atoms, a dialkylamino radical in which each alkyl portion contains 1 to 4 carbon atoms or, with the nitrogen atom to which it is linked, forms a saturated 5- or 6-membered heterocyclic radical optionally containing a second hetero atom chosen from oxygen, sulphur and nitrogen atoms (and optionally substituted with an alkyl radical containing 1 to 4 carbon atoms or a phenyl radical or a phenylalkyl radical in which the alkyl portion contains 1 to 4 carbon atoms), a carboxyl radical, an alkyloxycarbonyl radical in which the alkyl portion contains 1 to 4 carbon atoms, a cyano or carbamoyl radical, an N-alkylcarbamoyl radical in which the alkyl portion contains 1 to 4 carbon atoms or an N,N-dialkylarbamoyl radical in which each alkyl portion contains 1 to 4 carbon atoms or, with the nitrogen atom to which it is linked, forms a saturated 5- or 6-membered heterocyclic radical optionally containing a second hetero atom chosen from oxygen, sulphur and nitrogen atoms (and optionally substituted with an alkyl radical containing 1 to 4 carbon atoms or a phenyl radical or a phenylalkyl radical in which the alkyl portion contains 1 to 4 carbon atoms), or containing an oxygen, sulphur or nitrogen atom as hetero atom, and ##STR3## in which:
R.sub.1 represents a benzoyl radical optionally substituted with one or more identical or different atoms or radicals chosen from halogen atoms and alkyl radicals containing 1 to 4 carbon atoms, alkoxy radicals containing 1 to 4 carbon atoms or trifuloromethyl radicals, a thenoyl or furoyl radical or a radical R.sub.2 --O--CO-- in which R.sub.2 represents: containing 2 to 8 carbon atoms, an alkynyl radical containing 3 to 8 carbon atoms, a cycloalkyl radical containing 3 to 6 carbon atoms or a cycloalkenyl radical containing 4 to 6 carbon atoms or a bicycloalkyl radical containing 7 to 10 carbon atoms, these radicals being optionally substitute with one or more substitutents chosen from halogen atoms and hydroxyl radicals, alkoxy radicals containing 1 to 4 carbon atoms, dialkylamino radicals in which each alkyl portion contains 1 to 4 carbon atoms, piperidino or morpholino radicals, 1-piperazinyl radicals (optionally substituted at position 4 with
REFERENCES:
patent: 5254580 (1993-10-01), Chen et al.
patent: 5532388 (1996-07-01), Bouchard et al.
patent: 5550261 (1996-08-01), Bouchard et al.
patent: 5571917 (1996-11-01), Bouchard et al.
patent: 5576450 (1996-11-01), Bouchard et al.
patent: 5580997 (1996-12-01), Bouchard et al.
patent: 5580998 (1996-12-01), Bouchard et al.
patent: 5587493 (1996-12-01), Bouchard et al.
patent: 5599942 (1997-02-01), Bouchard et al.
English Abstract of French Patent No. FR 2 698 871-A1, Jun. 10, 1994.
Bouchard Herve
Bourzat Jean-Dominique
Commer.cedilla.on Alain
Rhone-Poulenc Rorer S.A.
Trinh Ba K.
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