Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-01-08
1998-09-22
Trinh, Ba K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549510, 549511, A61K 31335, C07D30514
Patent
active
058114521
ABSTRACT:
The present invention is directed to novel taxoids possessing strong reversing activities for drug-resistance associated with anti-cancer agents, the preparation of these reversal agents and pharmaceutical compositions thereof. The new taxoids of the present invention have the formula (I). ##STR1##
REFERENCES:
patent: 5264591 (1993-11-01), Bombardelli et al.
patent: 5283253 (1994-02-01), Holton et al.
patent: 5284864 (1994-02-01), Holton et al.
patent: 5284865 (1994-02-01), Holton et al.
patent: 5350866 (1994-09-01), Holton et al.
patent: 5475011 (1995-12-01), Ojima et al.
Ojima, et al., "A New Paclitaxel Photoaffinity Analog with a 3-(4-Benzoylphenyl)propanoyl Probe for Characterization of Drug-Binding Sites on Tubulin and P-Glycoprotein," Journal of Medicinal Chemistry, vol. 38, No. 20 (1995).
Kobayashi, et al., "Taxuspines A.about.C, New Taxoids from Japanese Yew Taxus Cuspidata Inhibition Drug Transport Activity of P-Glycoprotein in Multidrug-Resistant Cells," Tetrahedron, vol. 50, No. 25, pp. 7401-7416 (1994).
Bernacki Ralph J.
Ojima Iwao
Health Research Inc
The Research Foundation of State University of New York
Trinh Ba K.
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