Taxoid-fatty acid conjugates and pharmaceutical compositions...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C549S510000, C514S449000, C554S118000

Reexamination Certificate

active

07820839

ABSTRACT:
The invention relates to a second-generation-fatty acid conjugate and pharmaceutical compositions thereof. The second-generation-fatty acid conjugate are useful in the treatment of cancer in a human in need thereof.

REFERENCES:
patent: 5795909 (1998-08-01), Shashoua et al.
patent: 5919815 (1999-07-01), Bradley et al.
patent: 6080877 (2000-06-01), Swindell et al.
patent: 6576636 (2003-06-01), Webb et al.
patent: WO 2005/041881 (2005-05-01), None
Bradley, et al. “Tumor Targeting by Covalent Conjugation of a Natural Fatty Acid to Paclitaxel”Clinical Cancer Researchvol. 7:3229-3238 (2001).
Interview with Nigel Webb “Better Benefits, Fewer Risks”, Pharmaceutical Executive May 2001.
Ojima, et al. “Synthesis and Structure-Activity Relationships of New Second-Generation Taxoids,”Bioorg. Med. Chem. Lett., 9:3423-3428 (1999).
Ojima, et al. “Synthesis and Struture-Activity Relationships of the Second-Generation Antitumor Taxoids: Exceptional Activity against Drug-Resistant Cancer Cells,”J. Med. Chem. 39:3889-3896 (1996).
Vredenburg, et al. “Effects of Orally Active Taxanes on P-Glycoprotein Modulation and Colon and Breast Carcinoma Drug Resistance,” Journal of the National Cancer Institute 93(16):1234-1245 (Aug. 2001).

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