Taxoid compound and method for producing the same

Details Taxoid compound and method for producing the same Taxoid compound and method for producing the same

2000-02-15

2000-10-24

Lambkin, Deborah C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 60, 5462817, C07D30514, C07D40900, C07D40500

Patent

active

06136990&

ABSTRACT:
A taxoid compound represented by general formula (I) ##STR1## where the symbols R.sup.1, R.sup.2, R.sup.3, R.sup.4, Bz, and Ac have specified meanings. Also, a method for producing the taxoid derivative from a baccatin derivative having a .beta.-ketoester group at the 13-position by transesterification and a method for producing taxoid compound such as paclitaxel from the taxoid derivative under mild condition are disclosed.

REFERENCES:
patent: 6040466 (2000-03-01), Bouchard et al.
patent: 6043382 (2000-03-01), Nicolaou et al.
patent: 6051724 (2000-04-01), Holton et al.
patent: 6066747 (2000-03-01), Holton et al.
patent: 6066748 (2000-05-01), Han et al.
patent: 6066749 (2000-05-01), Sisti et al.

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