Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-c

Details Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-c Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-c

1995-06-05

1998-04-14

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549511, C07D30514

Patent

active

057393621

ABSTRACT:
Taxane derivatives having an alkoxy, alkenoxy or aryloxy substituted C13 side chain.

REFERENCES:
patent: 4680391 (1987-07-01), Firestone et al.
patent: 4814470 (1989-03-01), Colin et al.
patent: 4857653 (1989-08-01), Colin et al.
patent: 4876399 (1989-10-01), Holton et al.
patent: 4924011 (1990-05-01), Denis et al.
patent: 4924012 (1990-05-01), Colin et al.
patent: 4942184 (1990-07-01), Haugwitz et al.
patent: 5015744 (1991-05-01), Holton
patent: 5136060 (1992-08-01), Holton
patent: 5175315 (1992-12-01), Holton
patent: 5227400 (1993-07-01), Holton et al.
patent: 5229526 (1993-07-01), Holton
patent: 5243045 (1993-09-01), Holton et al.
patent: 5250683 (1993-10-01), Holton et al.
patent: 5254703 (1993-10-01), Holton
patent: 5264591 (1993-11-01), Bombardelli et al.
patent: 5274124 (1993-12-01), Holton
patent: 5283253 (1994-02-01), Holton et al.
patent: 5284864 (1994-02-01), Holton et al.
patent: 5284865 (1994-02-01), Holton et al.
patent: 5290957 (1994-03-01), Correa et al.
patent: 5292921 (1994-03-01), Correa et al.
patent: 5336785 (1994-08-01), Holton
patent: 5338872 (1994-08-01), Holton et al.
patent: 5350866 (1994-09-01), Holton et al.
patent: 5384399 (1995-01-01), Holton
patent: 5399726 (1995-03-01), Holton et al.
patent: 5405972 (1995-04-01), Holton et al.
patent: 5430160 (1995-07-01), Holton
patent: 5466834 (1995-11-01), Holton
patent: 5489601 (1996-02-01), Holton et al.
patent: 5532363 (1996-07-01), Holton
patent: 5539103 (1996-07-01), Holton
V. Farina et al. "The Chemistry of Taxanes: Unexpected Rearrangement of Baccatin III During Chemoselective Debenzoylation with Bu.sub.3 SnOMe/LiCl" Tetrahedron Letters vol. 33, No. 28, pp. 3979-3982, 1992.
D. Kingston et al. "Progress In the Chemistry Of Organic Natural Products" Springer-Verlag, New York (1993) pp. 1-206.
G. Samaranayake et al., "Modified Taxols. 5. Reaction of Taxol With Electrophilic Reagents And Preparation of A Rearranged Taxol Derivative With Tublin Assembly Activity" J. Org. Chem., vol. 56, No. 17, pp. 5114-5119 (1991).
International Search Report issued for PCT/US93/10813 dated Mar. 11, 1994.
G. Georg et al., "Novel Biologically Active Taxol Analogues: Baccatin III 13--(N-(p-Chlorobenzoyl)-(2'R, 3'S)-3'-phenylisoserinate) and Baccatin III 13--(N-Benzoyl-(2'R, 3'S)-3'-(p-chlorophenyl) isoserinate)" Bioorganic & Medicinal Chemistry Letters, vol. 2, No. 4, pp. 295-298 (1992).
Holton et al., "A Synthesis of Taxusin", JACS 110: 6568 (1988).
Wani et al., "Plant Antitumor Agents. VI. The Isolation and Structure of Taxol, a Novel Antileukemic and Antitumor Agent from Taxus Brevifolia", JACS 93: 9, pp. 2325-2327 May 5, 1971.
Holton, "Synthesis of the Taxane Ring System", JACS 106, pp. 5731-5732 (1984).
Mukerjee et al., ".beta.-Lactams: Retrospect and Prospect", Tetrahedron vol. 34, Report No. 52, pp. 1731-1767 (1978).
Science / Technology "New Family of Taxol, Taxotere Analogs Developed", Chem. & Engineering News, pp. 26-27 (Apr. 12, 1993).
Senilh et al., "Chime Organique Biologique--Hemisynthese de nouveaux analogues du taxol. Etude de leur interaction avec la tubuline", C.R. Acad. Sc. Paris, t. 299, Serie II, No. 15, pp. 1039-1043 (1984).
Ojima et al., "New and Efficient Approaches to the Semisynthesis of Taxol and its C-13 Side Chain Analogs by Means of .beta.-Lactam Synthon Method", Tetrahedron vol. 48, No. 34, pp. 6985-7012 (1992).
Denis & Green, A Highly Efficient, Practical Approach to Natural Taxol, JACS 110: 5917-5919 (1988).

Affiliated with

Also associated with

Rating

Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-c does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-c, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Taxanes having an alkoxy, alkenoxy or aryloxy substituted side-c will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-636393