Taxanes having a pyridyl substituted side-chain and pharmaceutic

Details Taxanes having a pyridyl substituted side-chain and pharmaceutic Taxanes having a pyridyl substituted side-chain and pharmaceutic

1993-07-20

1996-02-06

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514449, 546269, 549510, 549511, A61K 31335, A61K 3144, C07D40512, C07D30514

Patent

active

054896010

ABSTRACT:
Taxane derivatives having a 3' pyridyl substituted C13 side chain.

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Science/Technology "New Family of Taxol, Taxotere Analogs Developed", Chem. & Engineering News, pp. 26-27 (Apr. 12, 1993).
Ojima et al., "New and Efficient Approaches to the Semisynthesis of Taxol and its C-13 Side Chain Analogs by Means of .beta.-Lactam Synthon Method", Tetrahedron vol. 48, No. 34, pp. 6985-7012 (1992).
International Search Report issued for PCT/US93/10813 dated Mar. 11, 1994.
G. Georg et al., "Novel Biologically Active Taxol Analogues: Baccatin III 13-(N-(p-Chlorobenzoyl)-(2'R,3'S)-3'-phenylisoserinate) and Baccatin III 13-(N-Benzoyl-(2'R,3'S)-3'-(p-chlorophenyl)isoserinate)" Bioorganic & Medicinal Chemistry Letters, vol. 2, No. 4, pp. 295-298 (1992).

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