Taxanes covalently bounded to hyaluronic acid or hyaluronic...

Details Taxanes covalently bounded to hyaluronic acid or hyaluronic... Taxanes covalently bounded to hyaluronic acid or hyaluronic...

2011-01-21

2011-10-11

Jiang, Shaojia Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

Reexamination Certificate

active

08034795

ABSTRACT:
The present invention relates to water-soluble taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives, and in particular to paclitaxel and docetaxel, useful for the preparation of pharmaceutical compositions to be used in the field of oncology, in the treatment of autoimmune disorders and of restenosis. The invention also relates to the process for preparing taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivates by direct synthesis between molecules of hyaluronic acid and of taxane or by indirect synthesis by the introduction of a spacer between the hyaluronic acid derivative and the taxane.

REFERENCES:
patent: 5648506 (1997-07-01), Desai et al.
patent: 5977163 (1999-11-01), Li et al.
Luo et al, Bioconjugate Chem. 1999, 10, 755-763.
Sparer et al, Controlled Release Delivery Systems, Chapter 6, 1983, 107-119.

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