Taxane having antitumor activity

Details Taxane having antitumor activity Taxane having antitumor activity

1993-07-07

1995-04-18

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

514449, 514783, 560104, A61K 3578, A61K 31335, C07C 6976

Patent

active

054076749

ABSTRACT:
The present invention relates to a new taxane having the structure (1), which is isolatable from root bark of plants of the Taxus genus. The compound (1) is endowed with antitumor activity higher than the one of taxol, the former being active, unlike the latter, also against adriamicine resistant cells and as antileukemic drug. ##STR1##

REFERENCES:
patent: 4206221 (1980-06-01), Miller et al.
patent: 4942184 (1990-07-01), Haugwitz et al.
patent: 5157049 (1992-10-01), Haugwitz et al.
patent: 5227400 (1993-07-01), Holton et al.
patent: 5229526 (1993-07-01), Holton
patent: 5243045 (1993-09-01), Holton et al.
patent: 5250683 (1993-10-01), Holton et al.
patent: 5250722 (1993-10-01), Bombardelli et al.

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