Taxane coatings for implantable medical devices

Details Taxane coatings for implantable medical devices Taxane coatings for implantable medical devices

2011-04-05

2011-04-05

Wax, Robert A (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C514S449000, C623S001300

Reexamination Certificate

active

07919108

ABSTRACT:
This disclosure relates to implantable medical devices coated with a taxane therapeutic agent, such as paclitaxel, in one or more solid form(s) having varying dissolution rates. Particularly preferred coatings comprise amorphous and/or solvated solid forms of taxane therapeutic agents that provide durable coatings that release the taxane over a desired period of time, which can be varied in the absence of a polymer by selecting the type and amount of solid forms of the taxane therapeutic agent in the coating. Other preferred embodiments relate to methods of coating medical devices and methods of treatment. The coatings can provide a sustained release of the taxane therapeutic agent within a body vessel without containing a polymer to achieve the desired rate of paclitaxel elution.

REFERENCES:
patent: 4739762 (1988-04-01), Palmaz
patent: 5133732 (1992-07-01), Wiktor
patent: 5292331 (1994-03-01), Boneau
patent: 5380299 (1995-01-01), Fearnot et al.
patent: 5421955 (1995-06-01), Lau et al.
patent: 5440056 (1995-08-01), Klein et al.
patent: 5609629 (1997-03-01), Fearnot et al.
patent: 5824049 (1998-10-01), Ragheb et al.
patent: 5873904 (1999-02-01), Ragheb et al.
patent: 6090127 (2000-07-01), Globerman
patent: 6096070 (2000-08-01), Ragheb et al.
patent: 6221153 (2001-04-01), Castor et al.
patent: 6299604 (2001-10-01), Ragheb et al.
patent: 6306166 (2001-10-01), Barry et al.
patent: 6530951 (2003-03-01), Bates et al.
patent: 6589546 (2003-07-01), Kamath et al.
patent: 6599275 (2003-07-01), Fischer, Jr.
patent: 6689802 (2004-02-01), DiMarco et al.
patent: 6730064 (2004-05-01), Ragheb et al.
patent: 6774278 (2004-08-01), Ragheb et al.
patent: 6858644 (2005-02-01), Benigni et al.
patent: 6878832 (2005-04-01), Saiji
patent: 6918927 (2005-07-01), Bates et al.
patent: 6977085 (2005-12-01), Werling et al.
patent: 6982276 (2006-01-01), DiMarco et al.
patent: 7060285 (2006-06-01), Muller
patent: RE39251 (2006-08-01), Guo
patent: 7153879 (2006-12-01), DiMarco et al.
patent: 2002/0142050 (2002-10-01), Straub et al.
patent: 2003/0028243 (2003-02-01), Bates et al.
patent: 2003/0028244 (2003-02-01), Bates et al.
patent: 2003/0036794 (2003-02-01), Ragheb et al.
patent: 2003/0144344 (2003-07-01), Benigni et al.
patent: 2003/0236513 (2003-12-01), Schwarz et al.
patent: 2004/0039441 (2004-02-01), Rowland et al.
patent: 2004/0047909 (2004-03-01), Ragheb et al.
patent: 2004/0063977 (2004-04-01), Saiji
patent: 2004/0068241 (2004-04-01), Fischer, Jr.
patent: 2004/0073284 (2004-04-01), Bates et al.
patent: 2004/0243225 (2004-12-01), Ragheb et al.
patent: 2006/0079526 (2006-04-01), Wrasidlo et al.
patent: 2006/0116420 (2006-06-01), Chidambaram et al.
patent: 0 717 041 (1996-06-01), None
patent: 0717041 (1996-06-01), None
patent: 0734 721 (1996-10-01), None
patent: 7-289630 (1995-11-01), None
patent: WO 93/10076 (1993-05-01), None
patent: WO 00/32238 (2000-06-01), None
patent: WO 03/006180 (2003-01-01), None
Lee, et al., Bull. Dorean Chem. Soc., vol. 22, No. 8, 2001.
Gi, Korean J. Chem. Eng., 21 (4), 2004.
Lee, Bull. Korean Chem. Soc., 2001.
Chen, Int. J. Pharm., 2005.
Kamath, K. R. et al. “The Taxus drug-eluting stent: A new paradigm in controlled delivery”, Adv. Drug Delivery Reviews, vol. 58, No. 3, pp. 412-436 (2006).
International Search Report for PCT/US2007/006223.
Jeong Hoon Lee, Un-Sook Gi, Jin-Hyun Kim, Yongae Kim, Hunseung Oh and Bumchan Min, “Preparation and Characterization of Solvent Induced Dihydrated, Anhydrous, and Amorphous Paclitaxel,”Bull. Korean Chem. Soc., 2001, vol. 22, No. 8, 925-928.
Richard T. Liggins, W.L. Hunter, and Helen M. Burt, “Solid-State Characterization of Paclitaxel,”Journal of Pharmaceutical Sciences, vol. 86, No. 12, Dec. 1997, 1458-1463.
Anil K. Singla, Alka Garg, Deepika Aggarwal, “Paclitaxel and its formulations,”International Journal of Pharmaceutics, 235 (2002) 179-192.

Affiliated with

Also associated with

Rating

Taxane coatings for implantable medical devices does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Taxane coatings for implantable medical devices, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Taxane coatings for implantable medical devices will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2708287