Taxane-based prodrugs

Details Taxane-based prodrugs Taxane-based prodrugs

1997-02-03

1998-10-20

Trinh, Ba K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549510, 549511, 528421, A61K 31335, C07D30514

Patent

active

058247017

ABSTRACT:
Taxane-based compositions of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of aryls, substituted aryls, aralkyls, substituted aralkyls, alkyls and substituted alkyls;

REFERENCES:
patent: 5284865 (1994-02-01), Holton et al.
patent: 5411984 (1995-05-01), Kingston et al.
patent: 5422364 (1995-06-01), Nicolaou et al.
patent: 5489589 (1996-02-01), Wittman et al.
patent: 5530020 (1996-06-01), Gunawardana et al.
patent: 5547981 (1996-08-01), Greenwald et al.
patent: 5622986 (1997-04-01), Greenwald et al.
patent: 5681964 (1997-10-01), Ashton et al.
Georg, G. et al., "Synthesis and Biology of Substituted 3'-Phenyl Taxol Analogues",Bioorganic and Med. C Letters, vol. 4, No. 19; pp. 2231-2236, (1994).
Georg, G. et al., "Selective C-2 and C-4 Deacylation and Acylation of Taxol: The First Synthesis of a C-4, Substituted Taxol Analogue", Tetrahedron Letters, vol. 35, No. 48; pp. 8931-8934, (1994).
Ueda Y. et al., "Synthesis and Antitumor Evaluation of 2'-Oxycarbonylpaclitaxels (Paclitaxel-2'-Carbonates)", Bioorganic and Med. Chem. Letters; vol. 4, No. 15; pp. 1861-1864, (1994).
Ueda Y. et al., "Novel, Water-Soluble Phosphate Derivaties of 2'-Ethoxy Carbonylpaclitaxel as Potential Prodrugs of Paclitaxel: Syntheses and Antitumor Evaluation",Bioorg.& Med. Chem. Ltrs; vol. 5 No. 3: pp. 247-252; (1995).

Affiliated with

Also associated with

Rating

Taxane-based prodrugs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Taxane-based prodrugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Taxane-based prodrugs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-244785