Taxane and baccatin III analogs bearing new C2 and C4 functional

Details Taxane and baccatin III analogs bearing new C2 and C4 functional Taxane and baccatin III analogs bearing new C2 and C4 functional

1995-01-13

1996-12-24

Trinh, Ba K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549214, 549228, 549510, 549511, C07D31770, C07D30514

Patent

active

055874894

ABSTRACT:
Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C2 substituent other than benzoate and/or a C4 substituent other than acetate in which the C2 benzoate substituent and/or the C4 acetate substituent of a derivative of baccatin III or 10-desacetyl baccatin III is/are selectively reduced to the corresponding hydroxy group(s) and converted to R.sub.7 COO-- and/or R.sub.8 COO--, respectively, wherein R.sub.7 and R.sub.8 are independently H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.2 alkenyl, C.sub.2 -C.sub.6 alkynyl, moncyclic aryl, or monocyclic heteroaryl.

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