Taste masking with silicon dioxide

Details Taste masking with silicon dioxide Taste masking with silicon dioxide

1999-12-15

2001-05-15

Jarvis, William R. A. (Department: 1614)

Drug, bio-affecting and body treating compositions

Topical sun or radiation screening, or tanning preparations

Aromatic acid or derivative containing

C514S974000, C514S770000

Reexamination Certificate

active

06231838

ABSTRACT:

FIELD OF THE INVENTION
The present invention relates to the removal or masking of the taste of malflavored organic sunscreens in lip and oral cavity application products.
BACKGROUND OF THE INVENTION
Lip application products usually contain flavoring and sweetening agents to mask any malflavor of ingredients in the product. These agents, however, frequently fail to effectively mask the malflavor.
European Patent Application No. 345,787 discloses a method for fabricating tablets by a wet granulation process. The process involves absorbing colloidal silicon dioxide onto an unpleasant flavored drug. Once the granulation process is completed, the mixture is dried in an oven, milled, and tableted. The resulting tablets each contain from 5 to 20 percent by weight of silicon dioxide based on 100 percent weight of the tablet.
World Patent Application No. WO 94/28870 discloses an improved chewable cold/sinus medication which is incorporated onto an absorbant material. The absorbant material contains from about 5 to about 95 percent by weight of silicon dioxide based on 100 percent weight of total drug adsorbate preparation.
There is a continuing need to provide taste-masking agents for malflavored lip and oral cavity application products.
SUMMARY OF THE INVENTION
The present invention provides a composition which includes one or more organic suncreens and colloidal silicon dioxide. Preferably, the colloidal silicon dioxide is prewetted with a liquid, such as liquid silicone.
In another embodiment, the present invention provides a composition for topical application to the lips or oral cavity. The composition includes a topically applicable anhydrous base; one or more malflavored organic sunscreens; and a malflavored organic sunscreen taste-masking effective amount of colloidal silicon dioxide.
In yet another embodiment, a method of preparing these compositions is provided. The method includes the steps of (a) mixing silicon dioxide and a liquid, such as liquid silicone; (b) adding the mixture of step (a) to a melted anhydrous base material; (c) adding an organic sunscreen to the mixture of step (b); and (d) cooling the mixture of step (c).
DETAILED DESCRIPTION OF THE INVENTION
The present invention is directed to a composition which removes or masks the taste of malflavored organic suncreens with colloidal silicon dioxide. Malflavored organic sunscreens include, but are not limited to, unpleasant, off flavored, and bitter tasting organic sunscreens. Generally, these compositions are applied topically to the lips or oral cavity.
According to one embodiment of the present invention, the composition includes (a) a topically applicable anhydrous base; (b) a malflavored organic sunscreen; and (c) a malflavored organic sunscreen taste-masking effective amount of colloidal silicon dioxide. Preferably, the colloidal silicon dioxide is wetted colloidal silicon dioxide.
The anhydrous base may include, but is not limited to, petrolatum; silicones; oils, such as aloe vera oil; lanolin; vitamin E; waxes, such as carnauba wax, wax paraffin, white wax, and waxenol; cetyl alcohol; oleyl alcohol; preservatives; flavorants; colorants; and any combination of any of the foregoing. The composition broadly contains from about 65 to about 95 percent by weight and preferably from about 75 to about 90 percent by weight of anhydrous base, based upon 100 percent by weight of total composition.
Organic sunscreens suitable for use in the present invention include, but are not limited to, octocrylene, octylmethoxycinnamate, octylsalicylate, oxybenzone, and any combination of any of the foregoing. The composition generally contains from about 1 to about 40 percent by weight and preferably from about 3.5 to about 25 percent by weight, based upon 100 percent by weight of total composition.
Suitable colloidal silicon dioxides include, but are not limited, fumed silica, such as Aerosil™ 200 available from Degussa of Ridgefield Park, N.J. and Cab-O-Sil™ available from Cabot Corp. of Kokoma, Ind. The colloidal silicon dioxide preferably has a density of from about 0.04 to about 0.12 g/cc and a surface area of from about 130 to about 390 m
2
/g. According to one preferred embodiment, the colloidal silicon dioxide has a density of about 0.05 g/cc and a surface area of about 200 m
2
/g.
Colloidal silicone dioxide is generally a fine fluffy material which is often difficult to mix with other ingredients without producing environmentally hazardous dust. The present inventors have discovered that when colloidal silicon dioxide is prewetted with a liquid, such as liquid silicone, it may be mixed with other ingredients without producing hazardous dust. Other suitable liquids include, but are not limited to, polyphenylmethylsiloxane; cyclomethicone; dimethicone; dimethicone copolyol; mineral oil; liquid sunscreens, such as octocrylene and octylmethoxycinnamate; glycerin; propylene glycol; polyethylene glycol; and any combination of any of the foregoing. The silicon dioxide is therefore wetted with a liquid before being mixed with other components of the composition.
The composition contains a malflavored organic sunscreen taste-masking effective amount of colloidal silicon dioxide. The composition typically contains from about 0.05 to about 2 percent by weight and preferably from about 0.1 to about 2 percent by weight of colloidal silicon dioxide, based upon 100 percent weight of total composition. At concentrations above 1 percent, the silicon dioxide may impart a metallic taste to the composition.
Other flavorants, including, but not limited to, sweetening agents, such as saccharin, may be included in the composition. The composition may also contain other adjuvants including, but not limited to, colorants; non-organic sunscreens, such as titanium dioxide; perfume; and any combination of any of the foregoing.
The composition may be formed or incorporated into various lip and oral cavity application products, such as lip balm, lip ointment, cold sore ointment, lipstick, lip gloss, sunscreen face stick, lip gel, and lip lotion. The composition of the present invention may be topically applied to the lips or the oral cavity of an animal, such as a human, in need of the composition to prevent or treat sun exposure of the lips or oral cavity.
The composition of the present invention typically may be prepared as follows. Silicon dioxide is mixed, i.e., prewetted, with a liquid, such as liquid silicone. The prewetted silicon dioxide is added to a melted anhydrous base material. Typically, the anhydrous base material is melted at a temperature ranging from about 150 to about 160° F. The mixture is preferably maintained at a temperature of from about 150 to about 160° F. One or more organic sunscreens are added to the wetted silicon dioxide/anhydrous base material mixture. The mixture is then cooled to produce a composition of the present invention.
DESCRIPTION OF THE PREFERRED EMBODIMENTS
The following example is intended to describe the present invention without limitation.


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patent: 0 345 787 A2 (1989-12-01), None
patent: 0 345 787 B1 (1992-11-01), None
patent: 635218 (1995-01-01), None
patent: 9415580 (1994-07-01), None
patent: WO 94/28870 (1994-12-01), None

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