Taste masking compositions comprising spray dried microcapsules

Details Taste masking compositions comprising spray dried microcapsules Taste masking compositions comprising spray dried microcapsules

1989-10-03

1991-05-07

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424439, 424498, 424499, 424500, 424501, 427 3, A61K 958

Patent

active

050135570

ABSTRACT:
The present invention pertains to spray dried spheroidal microcapsules under about 150 microns in diameter which comprise in percentages by weight of the microcapsule composition (a) sucralfate present in an amount from about 1% to about 70%, and (b) a polymer soluble in the gastric fluids present in an amount from about 30% to about 99%. In another embodiment, the invention is directed at a taste masking composition which comprises a therapeutically effective amount of a spray dried spheroidal microcapsule core under about 150 microns in diameter and a matrix over the core wherein the taste masking composition comprises (A) a microcapsule core comprising in percentages by weight of the core composition (a) sucralfate present in an amount from about 1% to about 70%, and (b) a polymer soluble in the gastric fluids present in an amount from about 30% to about 99%; and (B) a matrix over the core comprising in percentages by weight of the matrix composition (a) a bulking agent present in an amount up to about 99.9%, and (b) a lubricating agent present in an amount from about 0.1% to about 7%.

REFERENCES:
patent: 3663253 (1972-05-01), Stone
patent: 4271142 (1981-06-01), Puglia et al.
patent: 4615697 (1986-10-01), Robinson
patent: 4704278 (1987-11-01), Wu
patent: 4716041 (1987-12-01), Kjornaes et al.
patent: 4824675 (1989-04-01), Wong et al.
patent: 4910023 (1990-03-01), Botzolakis

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