Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Food or edible as carrier for pharmaceutical
Patent
1997-10-01
2000-10-31
Spear, James M.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Food or edible as carrier for pharmaceutical
424465, 424466, 424490, 424494, 424495, 424497, 514937, 514963, 514974, A61K 920, A61K 950, A61K 958, A61K 962
Patent
active
061398659
ABSTRACT:
A taste-masked microcapsule composition for administration of a drug is provided. The composition comprises microcapsules of drug and a substantially water-insoluble polymeric material, typically a cellulosic polymer. The microcapsule composition may be incorporated into any number of pharmaceutical formulations, including chewable tablets, effervescent tablets, powders, liquid dispersions, and the like. A method for masking the taste of drugs is also provided, involving a phase separation coacervation technique in which drug is coated with relatively high levels of a polymeric material. These high coating levels give rise to effective taste masking, while nevertheless allowing targeted release of drug, so that the drug is released shortly after passage through the mouth.
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Friend David R.
Geoffroy Jean-Marie
Ng Steve
Sarabia Rafael E.
Weber Thomas P.
Eurand America, Inc.
Spear James M.
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