Tartrate salt of isofagomine and methods of use

Details Tartrate salt of isofagomine and methods of use Tartrate salt of isofagomine and methods of use

2011-01-04

2011-01-04

Andres, Janet L (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07863453

ABSTRACT:
A novel tartaric acid salt of Isofagomine (Isofagomine tartrate) that can be used for the treatment of Gaucher disease is provided. The invention also provides a crystalline form of isofagomine tartrate, method for preparing the salt, a pharmaceutical composition containing the salt, and a method of treating Gaucher disease.

REFERENCES:
patent: 5844102 (1998-12-01), Sierks et al.
patent: 6916829 (2005-07-01), Fan et al.
Stahl et al., Handbook of Pharmaceutical Salts-Properties, Selection and Use, Verlag Helvetica Chimica Acta, 2002).
Pandey, et al. “A general strategy towards the synthesis of 1-N-iminosugar type glycosidase inhibitors: demonstration by the synthesis of D- as well as L-glucose type iminosugars (isofagomines.” 2000, vol. 41(45), pp. 8821-8824.
Pandey, et al.; “A general strategy towards the synthesis of 1-N-iminosugar type glycosidase inhibitors: demonstration by the synthesis of D- as well as L-glucose type iminosugars (isofagomnes)” Tetrahedron Letters 41 (2000) pp. 8821-8824.

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