Targeting vector-phospholipid conjugates

Details Targeting vector-phospholipid conjugates Targeting vector-phospholipid conjugates

2011-07-26

2011-07-26

Desai, Anand (Department: 1656)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

C424S009520, C530S300000

Reexamination Certificate

active

07985402

ABSTRACT:
Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.

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