Targeting protein-diagnostic/therapeutic agent conjugates having

Details Targeting protein-diagnostic/therapeutic agent conjugates having Targeting protein-diagnostic/therapeutic agent conjugates having

1996-05-16

1998-08-18

Eisenschenk, Frank C.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Attached to antibody or antibody fragment or immunoglobulin;...

424 91, 424 153, 4241811, 5303913, A61K 5100, A61K 5110, C07K 1600

Patent

active

057955603

ABSTRACT:
Targeting protein-diagnostic/therapeutic agent conjugates joined by stabilized Schiff base linkages are disclosed. Schiff base linkage of targeting protein and agent is accomplished without exposure of the targeting protein to harsh oxidizing or reducing conditions. The cleavable, heterobifunctional linkers that are described provide certain advantages relating to in vivo administration of targeting protein conjugates, including controlled release of active agent at a target site.

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