Targeting PAX2 for the treatment of breast cancer

Details Targeting PAX2 for the treatment of breast cancer Targeting PAX2 for the treatment of breast cancer

2010-02-18

2011-12-20

Vivlemore, Tracy (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S023100, C536S024500, C435S320100, C424S178100, C514S001000

Reexamination Certificate

active

08080534

ABSTRACT:
The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the certain embodiments, the method of inhibiting expression of PAX2 is to administrate the subject a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 or by increasing expression of DEFB1 is also provided.

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