Targeting PAX2 for the induction of DEFB1-mediated tumor...

Details Targeting PAX2 for the induction of DEFB1-mediated tumor... Targeting PAX2 for the induction of DEFB1-mediated tumor...

2011-06-21

2011-06-21

Vivlemore, Tracy (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S024500, C435S320100

Reexamination Certificate

active

07964577

ABSTRACT:
Provided is a method of treating cancer in a subject by inhibiting expression of PAX2. An example of a cancer treated by the present method is prostate cancer. In the cancer treatment methods disclosed, the method of inhibiting expression of PAX2 can be by administration of a nucleic acid encoding an siRNA for PAX2. A method of treating cancer in a subject by administering DEFB1 is also provided. Similarly, provided is a method of treating cancer in a subject by increasing expression of DEFB1 in the subject.

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