Targeting of therapeutic agents using polysaccharides

Details Targeting of therapeutic agents using polysaccharides Targeting of therapeutic agents using polysaccharides

1992-08-27

1994-08-09

Kishore, G. S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424646, 435178, 514 2, 514 21, 514 54, 514169, 514179, 536 551, A01K 31715

Patent

active

053365062

ABSTRACT:
The invention relates to a method for the targeting of a therapeutic agent to a specific population of cells, wherein a complex is formed between the therapeutic agent and a polysaccharide capable of interacting with a cell receptor, and wherein the resulting complex is internalized into the cell by receptor mediated endocytosis (RME). In one embodiment of the invention, a complex of a therapeutic agent containing iron and the polysaccharide arabinogalactan may be formed and used to deliver iron specifically to hepatocytes by RME.

REFERENCES:
patent: 4501726 (1985-02-01), Schroder et al.
patent: 4770183 (1988-09-01), Groman et al.
patent: 4827945 (1989-05-01), Groman et al.
patent: 4861597 (1989-08-01), Kida et al.
patent: 4946675 (1990-08-01), Baldwin et al.
Wu et al., JBC, 263, p. 14621, (1988).
Fallon et al., Hepatology, 5, p. 899, 1985.
Meizer et al., Pharmaceutical Res., 6, 105, (1989).
Dasgupta et al., (1985), Biochemistry International, 10, pp. 327-338.
Ghosh et al., (1982), Proc. Indian. Natn. Sci. Acad., 48, pp. 12-19.
Ponpipom et al., (1983), Carbohydrate Research, 118, pp. 47-55.
International Search Report for International Application PCT/US91/09368 derived from U.S. patent application 07/630,017 described above.
Bodmer and Dean, (1985), Method in Enzymology, 112, pp. 298-306.
Brown et al., (1978), Arch. Bioch. Biophys., 188, pp. 418-428.
Dragsten et al., (1987), Biochim. Biophys. Acta, 926, pp. 270-279.
Fallon and Schwartz, (1985), Hepatology, 5, pp. 899-901.
Glicksman, ed., (1982), "Food Hydrocolloids", CRC Press, pp. 5 and 33.
Gorin and Barreto-Bergter in "The Polysaccharides", vol. 2, G. O. Aspinall, ed., Academic Press, 1983, pp. 376-380.
Harford and Ashwell in "The Glycoconjugates", vol. IV, M. I. Horowitz, ed., Academic Press, 1982, pp. 27-55.
Hamstra et al., (1980), JAMA, 243, pp. 1726-1731.
Henderson and Hillman, (1969), Blood, 34, pp. 357-375.
Martin, C. R., (1976), "Textbook of Endocrine Physiology", Williams & Wilkins, p. 21.
Meijer and van der Sluijs, (1989), Pharm. Res., 6, pp. 105-118.
Mukhopadhyay et al., (1989), Science, 244, pp. 705-707.
Ranade, V. V., (1989), J. Clin. Pharmacol., 29, pp. 685-694.
Stockert and Becker, (1980), Cancer Res., 40, pp. 3632-3634.
Wileman et al., (1985), Biochem. J., 232, pp. 1-14.
Wu and Wu, (1988), J. Biol. Chem., 263, pp. 14621-14624.
Lee et al., (1984), Biochemistry, 23, pp. 4255-4261.
Josephen et al., (1990), Magnetic Resonance Imaging, 8, pp. 637-646.

Affiliated with

Also associated with

Rating

Targeting of therapeutic agents using polysaccharides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Targeting of therapeutic agents using polysaccharides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Targeting of therapeutic agents using polysaccharides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-214932