Targeting of Notch3 receptor function for cancer therapy

Details Targeting of Notch3 receptor function for cancer therapy Targeting of Notch3 receptor function for cancer therapy

2008-09-11

2010-10-05

Bradley, Christina (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

07807630

ABSTRACT:
The present invention involves the use of peptides from Notch3, and antibodies that recognize epitopes represented by those peptides, as anti-cancer agents. Methods of combination therapy using standard anti-cancer protocols in conjunction with Notch3 peptides and antibodies also are provided.

REFERENCES:
patent: WO 98/05775 (1998-02-01), None
patent: WO 02/20722 (2002-03-01), None
patent: WO 03/042246 (2003-05-01), None
patent: WO 2005/017096 (2005-02-01), None
patent: WO 2006/047878 (2006-05-01), None
patent: WO 2008/076960 (2008-06-01), None
Peters et al. “Solid-phase synthesis of a fucosylated glycopeptide of human factor IX with a fucose- -( I->O)-serine linkage.” J. Chem. Soc. Perkins Trans., 1995, p. 3017-3022.
Viveros et al. “Characterization of a Novel Human Immunodeficiency Virus Type 1 Neutralizable Epitope within the Immunodominant Region of gp41,” Virology, 2000, 270, 135-145.
Rebay et al. “Specific EGF Repeats of Notch Mediate Interactions with Delta and Serrate: Implications for Notch as a Multifunctional Receptor,” Cell, 1991, 67, 687-699.
Hambleton et al. “Structural and Functional Properties of the Human Notch-1 Ligand Binding Region,” Structure, 2004, 12, 2173-2183.
Ahmad et al., “Involvement of Mash1 in EGF-mediated regulation of differentiation in the vertebrate retina,”Dev. Biol., 194:86-98, 1998.
Alves da Costa et al., “Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells,”J. Neurochem., 90:800-806, 2004.
Artavanis-Tsakonas et al., “Notch signaling: cell fate control and signal integration in development.,”Science, 284:770-776, 1999.
Barry et al., “Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells in MEK-independent,”J. Biol. Chem., 276: 15537-15546, 2001.
Beatus and Lendahl, “Notch and neurogenesis,”J. Neurosci. Res., 54:125-136, 1998.
Bellavia et al., “Combined expression of pTalpha and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis,”Proc. Natl. Acad. Sci. USA, 99:3788-3793, 2002.
Bellavia et al., “Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice,”EMBO J., 19:3337-3348, 2000.
Berset et al., “Notch inhibition of RAS signaling through MAP kinase phosphatase LIP-1 duringC. elegansvulval development,”Science, 291:1055-1058, 2001.
Brondello et al., “The dual specificity mitogen-activated protein kinase phosphate-1 and -2 are induced by the p42/p44MAPK cascade,”J. Biol. Chem., 272:1368-1376, 1997.
Callahan and Egan, “Notch signaling in mammary development and oncogenesis,”J. Mammary Gland Biol. Neoplasia., 9:145-163, 2004.
Campos et al., “Determinants of Notch-3 receptor expression and signaling in vascular smooth muscle cells: implications in cell-cycle regulation,”Circ. Res., 91:999-1006, 2002.
Curry et al., “Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells,”Oncogene, 24:6333-6344, 2005.
Dang et al., “Chromosome 19 translocation, overexpression of notch3, and human lung cancer,”Journal of the National Institute, 92:1355-1357, 2000.
Domenga et al., “Notch3 is required for arterial identity and maturation of vascular smooth muscle cells,”Genes Dev., 18:2730-2735, 2004.
Dovey et al., “Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain,”J. Neurochem., 76:173-181, 2001.
Ellisen et al., “TAN-1, the human homolog of theDrosophilanotch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms,”Cell, 66:649-661, 1991.
Faux et al., “Interactions between fibroblast growth factors and Notch regulate neuronal differentiation,”J. Neurosci., 21:5587-5596, 2001.
Fitzgerald et al., “Ras pathway signals are required for notch-mediated oncogenesis,”Oncogene, 19:4191-4198, 2000.
Haneda et al., “Mitogen-activated protein kinase phosphatase: a negative regulator of the mitogen-activated protein kinase cascade,”Eur. J. Pharmacol., 365:1-7, 1999.
Haruki et al., “Dominant-negative notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers,”Cancer Res., 65:3555-3561, 2005.
Hirsch et al., “Evaluation of HER-2
eu gene amplification and protein expression in non-small cell lung carcinomas,”Br. J. Cancer, 86:1449-1456, 2002.
Hrabe de Angelis et al., “Maintenance of somite borders in mice requires the Delta homologue DII1,”Nature, 386:717-721, 1997.
Jhappan et al., “Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands,”Genes Dev., 6:345-355, 1992.
Konishi et al., “γ-secretase inhibitor prevents notch3 activation and reduces proliferation in human lung cancers,”Cancer Res., 67:8051-8057, 2007.
Krebs et al., “Notch signaling is essential for vascular morphogenesis in mice,”Genes Dev., 14:1343-1352, 2000.
Lanford et al., “Notch signalling pathway mediates hair cell development in mammalian cochlea,”Nat. Genet., 21:289-292, 1999.
Levitan and Greenwald, “Facilitation of lin-12-mediated signalling by sel-12, aCaenorhabditis elegansS182 Alzheimer's disease gene,”Nature, 377:351-354, 1995.
Li et al., “Modulation of notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3,”Journal of Biological Chemistry, 283:8046-8054, 2008.
Linggi et al., “The ErbB-4 s80 intracellular domain is a constitutively active tyrosine kinase,”Oncogene, 25:160-163, 2006.
Lu et al., “Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis,”Clin. Cancer Res., 10:3291-3300, 2004.
Ma et al., “Hematological features and treatment outcome in acute myeloid leukemia with t(8;21),”Hematol. Oncol., 15:93-103, 1997.
Meert et al., “The role of EGF-R expression on patient survival in lung cancer: a systematic review with meta-analysis,”Eur. Respir. J., 20:975-981, 2002.
Miyamoto et al., “Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis,”Cancer Cell, 3:565-576, 2003.
Mumm and Kopan, “Notch signaling: from the outside in,”Dev. Biol., 228:151-165, 2000.
Paris et al., “Inhibition of angiogenesis and tumor growth by beta and gamma-secretase inhibitors,”Eur. J. Pharmacol., 514:1-15, 2005.
Pear et al., “Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles,”J. Exp. Med., 183:2283-2291, 1996.
Pelletier et al., “Gamma-secretase-dependent proteolysis of CD44 promotes neoplastic transformation of rat fibroblastic cells,”Cancer Res., 66:3681-3687, 2006.
Purow et al., “Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation,”Cancer Res., 65:2353-2363, 2005.
Qin et al., “p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas,”Mol. Cancer Ther., 3:895-902, 2004.
Robey et al., “An activated form of Notch influences the choice between CD4 and CD8 T cell lineages,”Cell, 87:483-492, 1996.
Rodenhuis et al., “Mutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: a prospective study,”J. Clin. Oncol., 15:285-291, 1997.
Rohn et al., “Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma,”J. Virol., 70:8071-8080, 1996.
Santagata et al., “JAGGED1 expression is ass

Affiliated with

Also associated with

Rating

Targeting of Notch3 receptor function for cancer therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Targeting of Notch3 receptor function for cancer therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Targeting of Notch3 receptor function for cancer therapy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4209395