Targeting of long chain triacylglycerol hydrolase gene for...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

Reexamination Certificate

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C424S009100, C424S009200, C424S130100, C424S139100, C424S150100, C424S184100, C424S185100, C424S190100, C424S234100, C530S300000, C530S350000, C536S023100, C536S023700

Reexamination Certificate

active

07601357

ABSTRACT:
Disclosed herein are novel methods for screening for compounds useful in treating or preventing tuberculosis. In exemplary embodiments, screening methods are based on the implementation or manipulation of triacylglycerol hydrolase like polypeptides or polynucleotides encoding the same. The methods are useful in identifying agents active against TB infection.

REFERENCES:
Deb, C., et al. A novel lipase belonging to the hormone-sensitive lipase family induced under starvation to utilize stored triacylglycerol in Mycobacterium tuberculosis. J. biol. Chem., vol. 281, No. 7, pp. 3866-3875, 2006.

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