Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing
Reexamination Certificate
2006-04-04
2006-04-04
Naff, David M. (Department: 1651)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
C424S009340, C424S009341, C424S094100, C435S004000, C435S174000, C435S177000, C530S402000, C530S810000
Reexamination Certificate
active
07022309
ABSTRACT:
Targeting molecules are provided for use in delivering imaging agents to epithelial tissue. The targeting molecule comprises a polypeptide that forms a closed covalent loop, contains at least three peptide domains having β-sheet character, each of the domains being separated by domains lacking β-sheet character. The targeting molecule specifically binds to a basolateral factor attached to a basolateral domain of an epithelial cell surface causing internalization of a linked imaging agent into the cells. The polypeptide or imaging agent may be linked to a peptide amino acid sequence that directs delivery of the imaging agent to a carcinoma cell, a nucleus, or an endoplasmic reticulum.
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Nagura
Fitchen John H.
Hein Mich B.
Hiatt Andrew C.
Biolex Newco I, Inc.
Naff David M.
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