Targeting drug/gene carriers to irradiated tissue

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing

Reexamination Certificate

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C424S130100, C424S141100, C424S450000

Reexamination Certificate

active

09975899

ABSTRACT:
The present invention provides a biomolecular carrier of pharmaceuticals, comprising: a biomolecule carrier bearing molecules that bind to a cellular adhesion molecule expressed on endothelial cell; and a pharmaceutical. The present invention also provides a method of treating a pathophysiological state in an individual in need of such treatment, comprising the steps of: irradiating a target tissue or organ in said individual; and administering to said individual the biomolecular carrier disclosed herein.

REFERENCES:
patent: 5962424 (1999-10-01), Hallahan
patent: 6159443 (2000-12-01), Hallahan
patent: WO 98/53852 (1998-12-01), None
Mastrobattista et al.,Biochim. Biophys. Acta, 1999, 1419, 353-363.
Patel et al ., FASEB 1998, vol. 12 pp. 1447-1454).

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