Targeting conjugates of albumin and therapeutic agents

Details Targeting conjugates of albumin and therapeutic agents Targeting conjugates of albumin and therapeutic agents

1985-12-31

1988-06-07

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Stabilized enzymes or enzymes complexed with nonenzyme

424 85, A61K 3748, A61K 39375

Patent

active

047495707

ABSTRACT:
The invention provides a conjugate comprising an enzyme having its antigenic sites or antigenicity masked by albumin and having a targeting agent attached, and a method for its preparation. The albumin is included in an amount sufficient to mask antigenicity of the enzyme. The targeting agent used has binding specificity for receptor sites on cells towards which it is desirable to direct the enzyme. Insulin, immunoglobulin G, antibody against human pancreatic tumor cell, and antibody against hyaluronic acid are exemplified as targeting agents.

REFERENCES:
patent: 4046722 (1977-09-01), Rowland
patent: 4110432 (1978-08-01), Wilkinson et al.
patent: 4161519 (1979-07-01), Talwar
patent: 4241177 (1980-12-01), Singh et al.
Remy, et al., The Lancet, Jul. 8, 1978, pp. 68-70.
Achord et al., Cell, vol. 15, pp. 269-278, 1978.
Tager, H., et al., Nature, vol. 281, pp. 122-125, 1979.
Basu, S., et al., Proc. Natl. Acad. Sci, vol. 73, pp. 3178-3182, 1976.
Cunningham, A., Understanding Immunology, Academic Press, New York, pp. 19-21, 1978.
Shier, W., et al., Int. J. Cancer, vol. 18, pp. 672-678, 1976.
Hurwitz, E., et al., Cancer Research, vol. 35, pp. 1175-1181, 1975.
Witztum, J., et al., Proc. Natl. Acad. Sci., vol. 80, pp. 2757-2761. 1983.

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