Targeting complexes and use thereof

Details Targeting complexes and use thereof Targeting complexes and use thereof

1995-12-19

1998-12-15

Ketter, James

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

A61K 4800

Patent

active

058497188

ABSTRACT:
The invention relates to a composition including a targeting complex containing a component of an effector system and a ligand capable of targeting a cell surface marker in association with at least one further targeting complex containiing a further component of the effector system and a ligand capable of targeting a cell surface marker which is a different cell surface marker to that targeted by at least one of the other targeting complexes, wherein the desired activity of the effector system is dependent on the selective internalization and functional cooperation of the components thereof.

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Orkin, S.H., et al., 1995. "Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy".
Furth et al., Proc. Natl. Acad. Sci. U.S.A. 91:9302-9306 (1994).
Garver et al., Gene Ther. 1:46-50 (1994).
Maxwell et al., Cancer Res. 51:4299-4304 (1991).
Maxwell et al., Chemical Abstracts, Abstract 113:18857, 87:189-204 (1989): UCLA Symposium Mol. Cell. Biol. New Ser. (Gene Transfer Gene Ther.) "Targeted Cell Suicide by Toxin Gene Expression".
Peterson and Tupy, Biochem. Pharm. 47(1): 127-128 (1994).
Robinson and Maxwell, Hum. Gene Ther. 6:137-143 (1994).
Smith et al., Hum. Gene Ther. 5:29-35 (1994).
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Yang et al., Hum. Gene Ther. 6:1203-1213 (1995).

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