Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-06-27
2006-06-27
Carlson, Karen Cochrane (Department: 1653)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Reexamination Certificate
active
07067633
ABSTRACT:
Methods of modulating macropinocytosis in cells of a target cell population by modulating the binding of Pak1 to DLC1/PIN are disclosed. In addition, the invention provides for methods of screening for modulators of macropinocytosis that involve determining whether a candidate substance inhibits or promotes the binding of Pak1 to DLC1/PIN. Also disclosed are methods of reducing cell proliferation in a target cell population, methods of inhibiting growth and survival of a cancer cell, methods of inhibiting the invasiveness of a cancer cell, and methods of treating viral infection using an agent that modifies the binding of Pak1 to DLC1/PIN.
REFERENCES:
Dharmawardhane, S., et al.; Regulation of Macropinocytosis by p21-activated Kinase-1, The American Society for Cell Biology (Oct. 2000) vol. 11, pp. 3341-3352.
Dharmawardhane, S., et al,; Localization of p21-Activated Kinase 1 (PAK1) to Pinocytic Vesicles and Cortical Actin Structures in Stimulated Cells, The Journal of Cell Biology, (Sep. 22, 1997), vol. 138, No. 6, pp. 1265-1278.
Hirokawa, N.; Kinesin and Dynein Superfamily Proteins and the Mechanism of Organelle Transport, (Jan. 23, 1998) Science, vol. 279, pp. 519-526.
Pazour, G., et al.; A Dynein Light Chain Is Essential for the Retrograde Particle Movement of Intraflagellar Transport (IFT), The Journal of Cell Biology, (May 18, 1998), vol. 141, No. 4, pp. 979-992.
Vallee, Richard B., et al.; Targeting of Motor Proteins, Science, (Mar. 15, 1996), vol. 271, pp. 1539-1544.
Vadlamudi, Ratna, K., et al.; Differential Regulation of Components of the Focal Adhesion Complex by Heregulin: Role of Phosphatase SHP-2, Journal of Cellular Physiology, (2002), vol. 190, pp. 189-199.
Vadlamudi, Ratna, K., et al.; Evidence of Rab3A Expression, Regulation of Vesicle Trafficking, and Cellular Secretion in Response to Heregulin in Mammary Epithelial Cells, American Society for Microbiology (Dec. 2000), vol. 20, No. 23, pp. 9092-9101.
Vadlamudi, Ratna, K., et al.; Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells, The Journal of Biological Chemistry, (Nov. 17, 2000), vol. 275, No. 46, pp. 36238-36244.
Vadlamudi, Ratna, K., et al.; Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1, Nature Cell Biology (Sep. 2002), vol. 4, pp. 681-690.
Kumar Rakesh
Vadlamudi Ratna
Board of Regents , The University of Texas System
Carlson Karen Cochrane
Fulbright & Jaworski LLP
Rooke Agnes
LandOfFree
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