Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or...
Patent
1998-03-27
2000-11-07
Weber, Jon P.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
4351734, 4351737, 424577, C12N 1300, A61K 3518
Patent
active
06143535&
ABSTRACT:
A method is presented to remove contaminating tumor cells from a cell population. The method includes labeling individual tumor cells in the population and then killing them with a high energy laser beam. The laser is focused so that it specifically kills the identified tumor cell, but not the remaining cells in the population.
REFERENCES:
patent: 4284897 (1981-08-01), Sawamura et al.
patent: 4395397 (1983-07-01), Shapiro
patent: 4532402 (1985-07-01), Overbeck
patent: 4624915 (1986-11-01), Schindler et al.
patent: 4629687 (1986-12-01), Schindler et al.
patent: 4803992 (1989-02-01), Lemelson
patent: 5035693 (1991-07-01), Kratzer et al.
patent: 5089384 (1992-02-01), Hale
patent: 5158889 (1992-10-01), Hirako et al.
patent: 5188633 (1993-02-01), Kratzer et al.
patent: 5272081 (1993-12-01), Weinreb et al.
patent: 5298963 (1994-03-01), Murakami et al.
patent: 5381224 (1995-01-01), Dixon et al.
patent: 5646411 (1997-07-01), Kain et al.
patent: 5672880 (1997-09-01), Kain
patent: 5690846 (1997-11-01), Okada et al.
patent: 5719391 (1998-02-01), Kain
patent: 5874266 (1999-02-01), Palsson
patent: 5932872 (1999-08-01), Price
Photonic Instruments, Inc.; Micro Point-Laser System For Bio-Medical and Life Sciences; Product Information Sheet, Apr., 1996.
Gribben, et al.; Antibody-mediated Purging; Bone Marrow Transplantation; Chapter 13, Boston-Blackwell Scientific Publications; pp. 149-163 (1994).
Rowley, Scott D.; Pharmacological Purging of Malignant Cells; Bone Marrow Transplantation; Chapter 14, Boston-Blackwell Scientific Publications; pp. 164-178 (1994).
Gee, Adrian P.; Part 5: Autologous Bone Marrow Purging; Bone Marrow Processing and Purging; pp. 248-328 (1991), CRC Press, Boca Raton.
Dooley, et al.; A Novel, Inexpensive Technique for the Removal of Breast Cancer Cells from Mobilized Peripheral Blood Stem Cell Products; Blood; vol. 88, p. 252a (1996), Abst. 995.
Greer, et al.; A Clonogenic Culture Method for the Identification of Breast Cancer Cells in Marrow Aspirates of Patients Receiving High-Dose Chemotherapy; Abstract 996, Blood (1996), vol. 88, p. 252a.
Thomas, et al.; Direct Purging of Breast Carcinoma Cells with Anti-CD24 and/or Anti-Breast Carcinoma Antibodies Using a Novel Immunomagnetic Cell Depletion System; Blood (1996), vol. 88, p. 252a, Abst 997.
Theocharous, et al.; The Detection and Genetic Analysis of Low Frequency Epithelial Tumour Cells in Patients with Breast Cancer; Blood (1996), vol. 88, p. 252a, Abstr 997.
Miller, et al.; Rapid Killing of Single Neurons by Irradiation of Intracellularly Injected Dye; Science; vol. 206; Nov. 9, 1979; pp. 702-704.
Lazarus, et al.; Does In Vitro Bone Marrow Purging Improve the Outcome after Autologous Bone Marrow Transplantation?; Journal of Hematotherapy; 1993; 2:457-466.
Gulati, et al.; Rationale for Purging in Autologous Stem Cell Transplantation; Journal of Hematotherapy; 1993; 2:467-471.
Brugger, et al.; Mobilization of Tumor Cells and Hematopoietic Progenitor Cells Into Peripheral Blood of Patients with Solid Tumors; Blood; vol. 83; No. 3; Feb. 1, 1994; pp. 636-640.
Rill, et al.; Direct Demonstration that Autologous Bone Marrow Transplantation for Solid Tumors Can Return a Multiplicity of Tumorigenic Cells; Blood; vol. 84; No. 2; Jul. 15, 1994; pp. 380-383.
Campana, et al.; Detection of Minimal Residual Disease in Acute Leukemia: Methodologic Advances and Clinical Significance; Blood; vol. 85; No. 6; Mar. 15, 1995; pp. 1416-1434.
Gazitt, et al.; Purified CD34+Lin-Thy+Stem Cells Do Not Contain Clonal Myeloma Cells; Blood; vol. 86; No. 1; Jul. 1, 1995; pp. 381-389.
Clarke, et al.; A recombinant bcl-xs adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells; Proc. Natl. Acad. Sci. USA; vol. 92; Nov. 1995; pp. 11024-11028.
Lydaki, et al.; Merocyanine 540 mediated photoirradiation of leukemic cells. In vitro inference on cell survival; Journal of Photochemistry and Photobiology B: Biology 32; pp. 27-32, 1996.
LandOfFree
Targeted system for removing tumor cells from cell populations does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Targeted system for removing tumor cells from cell populations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Targeted system for removing tumor cells from cell populations will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1639408