Targeted synthesis of protein in mammary gland of a non-human tr

Details Targeted synthesis of protein in mammary gland of a non-human tr Targeted synthesis of protein in mammary gland of a non-human tr

1994-01-25

1999-11-30

Crouch, Deborah

Multicellular living organisms and unmodified parts thereof and

Method of using a transgenic nonhuman animal to manufacture...

The protein is isolated or extracted from milk

800 14, 435 691, C12P 2100, A01K 67027

Patent

active

059946164

ABSTRACT:
Described are methods of targeting specific genes or DNA sequences encoding biologically active proteins to the mammary gland such that the DNA sequence is expressed in the mammary gland and the protein is secreted into the milk of the mammal. Also described is the production of transgenic nonhuman mammals whose germ line comprises a DNA gene complex containing a casein promoter, a casein enhancer, a DNA sequence which encodes a signal peptide and a DNA sequence encoding a biologically active protein. The milk containing the biologically active protein or the biologically active protein itself can be used in the making of diary products.

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