Targeted radioimmunotherapy

Details Targeted radioimmunotherapy Targeted radioimmunotherapy

1997-04-01

1999-07-20

Huff, Sheela

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

435 71, 4352831, 436528, 436529, 436530, 436531, 436532, 436804, 436807, 4241791, 4241801, 4241811, 424 149, 424422, 600 1, 600 3, 600 36, 604101, 606194, 606195, 623 1, 623 11, 623 12, A61K 39395, A61K 3940, A61K 3942, A61K 3944, A61F 1300, A61F 204, A61N 500, A61M 500

Patent

active

059253533

ABSTRACT:
A stent for the inhibition of restentosis. The stent is coated with an antigen which can be bound by a labelled antibody. The antibody is preferably labelled with a radioactive source. After the stent has been placed in the blood vessel of the subject, the antibody is injected. The antibody then binds to the antigen on the stent, thereby localizing the radioactive source to the area to be treated, for example for restenosis. Other biomedical devices, such as coil, artificial valve and vascular graft, could also be used in the place of the stent. The biomedical device could be placed in another biological passageway, such as the gastrointestinal tract, an airway or the genitourinary tract.

REFERENCES:
patent: 5131907 (1992-07-01), Williams et al.
patent: 5554182 (1996-09-01), Dinh et al.
patent: 5607475 (1997-03-01), Cahalan et al.

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