Targeted proteolysis by recruitment to ubiquitin protein...

Details Targeted proteolysis by recruitment to ubiquitin protein... Targeted proteolysis by recruitment to ubiquitin protein...

2007-05-29

2007-05-29

Slobodyansky, Elizabeth (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

C435S069700, C435S183000, C435S325000, C435S354000, C435S366000, C435S375000, C536S023400

Reexamination Certificate

active

09415795

ABSTRACT:
The present invention relates to methods and reagents for targeting proteolysis of a polypeptide by cis or trans association with a ubiquitin protein ligase, and further provides methods and reagents for inhibiting the ubiquitination and proteolysis of cellular proteins which are recognized by a ubiquitin protein ligase.

REFERENCES:
patent: 5252466 (1993-10-01), Cronan, Jr.
patent: WO 99/18989 (1999-04-01), None
Verma et al., (Sep. 18, 1997) Nature, vol. 389, pp. 239-242.
Kumar et al. (Mar. 1998) Proc. Natl. Acad. Sci., vol. 95 pp. 2417-2422.
Cohen et al. (Apr. 16, 2004) BMC Developmental Biology, vol. 4, pp. 1-7.
Feldman, R.M. et al. “A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor vSic1p”Cell91(2):221-230 (1997).
Li, F.N. et al. “GRRI of Saccharomyces Cerevisiae is Connected To The Ubuitin Proteolysis Machinery Through SKP1: Coupling Glucose Sensing to Gene Expression and The Cell Cycle”EMBO J.16(18): 5629-5638 (1997).
Patto, E.E. et al. “Combinatorial Control In Ubiquintin-dependent Proteolysis: Don't Skp the F-box Hypothesis”Trends Genet.14(6): 236-243 (1998).
Skowyra D. et al. “F-box Proteins Are Receptor That Recruits Phosphorylated Subatrates to the SCF Ubiquitin0ligase Complex”Cell91(2): 209-219, (1997).
Zhou, P et al. “Ubiquitination and Degradation of the Substrate Recognition Subunits of SCF Ubiquitin-protein Ligases”Molecular Cell2(5): 571-580 (1998).
Sheffner, M et al. (1991),The State of the p53 and Retinoblastoma Genes in Human Cervical Carcinoma Cell Lines, Proc. Natl. Acad. Sci. USA 88:5523.
Huitbregtse, J.M. et al. (1995),A Family of Proteins Structually and Functionally Related to the E6-AP Ubiquitin-Protein Ligase, Proc. Natl. Acad. Sci. USA 92:2563.
Scheffner, M. et al. (1993),The HPV-16 E6 and E6-AP Complex Functions as a Ubiquitin-Protein Ligase in the Ubiquitination of p53, CELL 75(3):495.
Huibregtse, J.M. et al. (1993),Localization of the E6-AP Regions that Direct Human Papillomarvirus E6 Binding, Association with p53, and Ubiquitination of associated Proteins, Mol. Cell Biol. 13(8):4918.
Scheffner, M. et al. (1992),Interaction of the Human Papillomavirus Type 16 E6 Oncoprotein with Wild-Type and Mutant Human p53 Proteins, J. VIROl. 66(8):5100.
Scheffner, M. et al. (1992),Targeted Degradation of the Retinoblastoma Protein by Human Papillomavirus E7-E6 Fusion Proteins, EMBO. J. 11(7):2425.
Munger, K. et al. (1992),Interactions of HPV E6and E7 Oncoproteins with Tumour Suppressor Gene Products, Cancer Surv. 12:197.
Huibregtse, J.M. et al. (1991),A Cellular Protein Mediates Association of p53 with the E6 Oncoprotein of Human Papillomarvirus Types 16 or 18, EMBO. J. 10(13):4129.

Affiliated with

Also associated with

Rating

Targeted proteolysis by recruitment to ubiquitin protein... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Targeted proteolysis by recruitment to ubiquitin protein..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Targeted proteolysis by recruitment to ubiquitin protein... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3804121