Targeted MR imaging agents

Details Targeted MR imaging agents Targeted MR imaging agents

2011-08-23

2011-08-23

Jones, D. L. (Department: 1618)

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

C424S001650, C424S009100, C424S009300, C424S009363, C424S009361, C424S001850, C424S001890

Reexamination Certificate

active

08003078

ABSTRACT:
MRI contrast agents that employ paramagnetic agents and chemical exchange saturation transfer (paraCEST) and which are coupled to targeted particulate delivery vehicles provide sufficient concentration of the paraCEST contrast agents to obtain useful images of target tissues or organs. In addition, the image contrast may be switched on or off with a presaturation radio frequency pulse, avoiding the necessity obtaining pre-injection and post-injection images.

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Winter et al., Magnetic Resonance in Medicine (2006) 56:1384-1388.

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