Targeted gene expression using preproendothelin-1 promoters

Details Targeted gene expression using preproendothelin-1 promoters Targeted gene expression using preproendothelin-1 promoters

1995-02-28

1998-05-05

Campbell, Bruce R.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

4351723, 4353201, 514 44, 536 241, 935 6, 935 34, 935 22, C12N 500, C12N 1500, C07H 2104

Patent

active

057473404

ABSTRACT:
This invention provides a vector for expression of a nucleic acid cassette in bronchial epithelial and vascular endothelial cells comprising a segment of the 5'-flanking region of the preproendothelin-1 gene, upstream from the transcription start site, the first exon of the preproendothelin-1 gene, and a nucleic acid cassette, wherein the nucleic acid cassette is located within the first exon, in sequential and positional relationship for expression of the nucleic acid cassette.

REFERENCES:
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Lee, et al., "Expression Of The Potent Vasoconstrictor Endothelin In The Human Central Nervous System", J. Clin. Invest., vol. 86, Jul. 1990, 141-147.
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Yanagisawa, et al., "A Novel Potent Vasoconstrictor Peptide Produced By Vascular Endothelial Cells", Nature, vol. 332, 31, Mar. 1988, 411-415.
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