Targeted forms of methyltrithio antitumor agents

Details Targeted forms of methyltrithio antitumor agents Targeted forms of methyltrithio antitumor agents

1996-02-16

2000-01-18

MacMillan, Keith D.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

4241791, 4241781, 514 12, 514 25, 514 26, 5303919, 5303917, A61K 39395

Patent

active

060155620

ABSTRACT:
The invention is humanized CT-M-01 monoclonal antibody molecule-drug conjugates prepared from the family of methyltrithio antitumor agents.

REFERENCES:
patent: 5053394 (1991-10-01), Ellestad et al.
Hird, V., et al., Immunotherpay with Monoclonal Antibodies. In:Genes and Cancer, Carney et al. (ed.) Wiley & Sons, 1990.
Queen C., et al., A humanized antibody that binds to the interleukin 2 receptor. Proc. Natl. Acad. Sci. vol. 86, pp. 10029-10033, 1989.
Riechman, L., et al., Reshaping human antibodies for therapy. Nature. vol. 332, pp. 323-327. 1988.
Waldmann, T.A., Monoclonal Antibodies in Diagnosis and Therapy. Science. vol., 252, pp. 1657-1662. 1991.

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