Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-04-19
2011-04-19
McGarry, Sean (Department: 1635)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091100, C435S325000, C435S375000, C514S04400A
Reexamination Certificate
active
07927792
ABSTRACT:
A method of killing a specific target cell/tissue is disclosed. The method comprises exposing the specific target cell/tissue to a composition-of-matter comprising a double stranded RNA molecule associated with a targeting moiety selected capable of targeting to the specific target cell/tissue, thereby killing the specific target cell/tissue.
REFERENCES:
patent: WO 94/23050 (1994-10-01), None
patent: WO 01/43777 (2001-06-01), None
patent: WO 03/078576 (2003-09-01), None
Abounader et al. The in vivo targeting of scatter factor/hepatocyte growth factor and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis. The FASEB Journal, Jan. 2002;16(1):108-10. Epub Nov. 29, 2001.
Czubayko et al. Melanoma angiogenesis and metastasis is modulated by a ribozyme targeted to the secreted growth factor pleiotrophin. Proc. Natl. Acad. Sci., 1996 vol. 93:14753-14758.
Zhao et al. Selective disruption of neuregulin-1 function in vertebrate embryos using ribozyme-tRNA transgenes. Development, 1998 vol. 125:1899-1907.
Yamazaki et al. (Journal of the National Cancer Institute, 1998 vol. 90:581-587).
Ogris et al. (Journal of Biological Chemistry, 2001 vol. 276:47550-47555).
Shir et al. EGF-Receptor-Targeted Synthetic Double-Stranded RNA Eliminates Glioblastoma, Breast Cancer, and Adenocarcinoma Tumors in Mice. PLOS Medicine, 2006 vol. 3, No. 1:0125-0135.
Ogris et al. “DNA/Polyethylenimine Transfection Particles: Influence of Ligands, Polymer Size, and PEGylation on Internatlization and Gene Expression”, AAPS PharmSci 3(3): Article 21: 1-11, 2001.
Sosnowski et al. “Targeting DNA to Cells with Basic Fibroblast Growth Factor (FGF2)”, Journal of Biological Chemistry 271(52): 33647-33653, 1996.
Xu et al. “The Contribution of Poly-L-Lysine, Epidermal Growth Factor and Streptavidin to EGF/PLL/DNA Polyplex Formation”, Gene Therapy 5: 1235-1243, 1998.
Shir et al. “Efficient Killing of Glioblastoma and Other Cancers by Cancer Specific Transfection of dsRNA”.
Shir et al. “Inhibition of Glioma Growth by Tumor-Specific Activation of Double-Stranded RNA-Dependent Protein Kinase PKR”, Nature Biotechnology 20(9): 895-900, 2002. Abstract.
Merdan et al. “Prospects for Cationic Polymers in Gene and Oligonucleotide Therapy Against Cancer”, Advanced Drug Delivery Reviews, 54(5): 715-758, 2002.
Blessing et al. “Different Strategies for Formation of PEGylated EGF-Conjugated PEI/DNA Complexes for Targeted Gene Delivery”, Bioconjugate Chemistry, 12(4): 529-537, 2001, Abstract.
Bettinger et al. “Peptide-Mediated RNA Delivery: A Novel Approach for Enhanced Transfection of Primary and Post-Mitotic Cells”, Nucleic Acids Research, 29(18): 3882-3891, 2001. Abstract.
Liu et al. “Double-Stranded Ribonucleic Acid (RNA) Induces β-Cell Fas Messenger RNA Expression and Increases Cytokine-Induced β-Cell Apoptosis”, Endocrinology, 142(6): 2593-2599, 2001. Abstract.
Shir et al. “EGF Receptor-Targeted Synthetic Double-Stranded RNA Eliminates Glioblastoma, Breast Cancer, and Adenocarcinoma Tumors in Mice”, PLoS Medicine, 3(1/e6): 0125-0135, 2006.
Bansal et al. “Gene Therapy for Brain Tumors”, Current Oncology Reports, 2: 463-472, 2000.
Bukrinsky et al. “A Nuclear Localization Signal Within HIV-1 Matrix Protein That Governs Infection of Non-Diving Cells”, Nature, 365: 666-669, 1993.
Eriksdotter Joenhagen “Intracerebroventricular Infusion of Nerve Growth Factor in Three Patients With Alzheimer's Disease”, Dementia and Geriatric Cognitive Disorders, 9: 246-257, 1998.
Farrell et al. “Interferon Action:Two Distinct Pathways for Inhibition of Protein Synthesis by Double-Stranded RNA”, Proc. Natl. Acad. Sci. USA, 75(12): 5893-5897, 1978.
Gallay et al. “HIV Nuclear Import Is Governed by the Phosphotyrosine-Mediated Binding of Matrix to the Core Domain of Integrase”, Cell, 83: 569-576, 1995.
George “Platelet-Derived Growth Factor Receptors: A Therapeutic Target in Solid Tumors”, Seminars in Oncology, 28(5/Suppl.17): 27-33, 2001.
Giles “The Vascular Endothelial Growth Factor (VEGF) Signaling Pathway: A Therapeutic Target in Patients With Hematologic Malignancies”, The Oncologist, 6(Suppl.5): 32-39, 2001.
Iordanov et al. “Activation of P38 Mitogen-Activated Protein Kinase and C-Jun NH2-Terminal Kinase by Double-Stranded RNA and Encephalomyocarditis Virus: Involvement of RNase L, Protein Kinase R, and Alternative Pathways”, Molecular and Cellular Biology, 20(2): 617-627, 2000.
Jagus et al. “PKR, Apoptosis and Cancer”, The Inernational Journal of Biochemistry & Cell Biology, 31: 123-138, 1999.
Kim et al. “Epidermal Growth Factor Receptor Biology”, Current Opinion in Oncology, 13(6): 506-513, 2001.
Lappi “Tumor Targeting Through Fibroblast Growth Factor Receptors”, Seminars in Cancer Biology, 6: 279-288, 1995.
Nagane et al. “Drug Resistance of Human Glioblastoma Cells Conferred by A Tumor-Specific Mutant Epidermal Growth Factor Receptor Through Modulation of Bcl-XL and Caspase-3-Like Proteases”, Proc. Natl. acad. Sci. USA, 95: 5724-5729, 1998.
Nakamura et al. “Effect of Interferon Inducer (Poly ICLC) in the Treatment of Malignant Brain Tumor”, No To Shinkei, 34(3): 267-273, 1982. Abstract, Article in Japanese. Abstract in English.
Nishikawa et al. “A Mutant Epidermal Growth Factor Receptor Common in Human Glioma Confers Enhanced Tumorgenicity”, Proc. Natl. Acad. Sci. USA, 91: 7727-7731, 1994.
Player et al. “The 2-5A System: Modulation of Viral and Cellular Processes Through Acceleration of RNA Degradation”, Pharmacological Therapy, 78(2): 55-113, 1998.
Rosen “Angiogenesis Inhibition in Solid Tumors”, Cancer Journal, 7(Suppl.3): 120-128, 2001.
Salazar et al. “Long-Term Treatment of malignant Gliomas With Intramuscularly Administered Polyinosinic-Polycytidylic Acid Stabilized With Polylysine and Carboxymethylcellulose: An Open Pilot Study”, Congress of Neurological Surgeons, 38(6): 1096-1104, 1996.
Shir et al. “Gene Therapy for Glioblastoma: Future Perspective for Delivery Systems and Molecular Targets”, Cellular and Molecular Neurobiology, 21(6): 645-656, 2001.
Singh “Transferrin as A Targeting Ligand for Liposomes and Anticancer Drugs”, Current Pharmaceutical Design, 5: 443-451, 1999.
Von Schwedler et al. “The Nuclear Localization Signal of the Matrix Protein of Human Immunodeficiency Virus Type 1 Allows the Establishment of Infection in Macrophages and Quiescent T Lymphocytes”, Proc. Natl. Acad. Sci. USA, 91: 6992-6996, 1994.
Wang et al. “Insulin-Like Growth Factor Receptor-1 as An Anti-Cancer Target: Blocking Transformation and Inducing Apoptosis”, Current Cancer Drug Targets, 2: 191-207, 2002.
Communication Pursuant to Article 94(3) EPC Dated Mar. 11, 2009 From the European Patent Office Re.: Application No. 03772616.3.
Communication Pursuant to Article 94(3) EPC Dated Oct. 23, 2009 From the European Patent Office Re.: Application No. 03772616.3.
Supplementary European Search Report Dated Aug. 8, 2006 From the European Patent Office Re.: Application No. 03772616.3.
Translation of Notice of Reason for Rejection Dated Mar. 12, 2010 From the Japanese Patent Office Re.: Application No. 2004-553056.
Chacko et al. “Double-Stranded Ribonucleic Acid Decreases C6 Rat Glioma Cell Proliferation in Part by Activating Protein Kinase R and Decreasing Insulin-Like Growth Factor I Levels”, Endocrinology, 143(6): 2144-2154, Jun. 2002.
Collins et al. “Gene and Chromosomal Alterations Associated With the Development of Human Gliomas”, The FASEB Journal, 7(10): 926-930, 1993.
International Search Report Dated Jun. 1, 2004 From the International Searching Authority Re.: Application No. PCT/IL03/00957.
Communication Pursuant to Article 96(2) EPC Dated Nov.
Levitzki Alexander
Shir Alexei
Gibbs Terra Cotta
McGarry Sean
Yissum Research Development Company of the Hebrew University of
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